NCT02527980.

Study name	E‐cigarettes: dynamic patterns of use and health effects
Methods	Prospective observational study Setting: community, USA Recruitment: People who smoke and dual EC and cigarette users
Participants	Estimated enrolment: 450 Inclusion criteria: ≥ 18 years old No plans to quit smoking and/or EC use in the next 30 days Not currently taking smoking cessation medication Not currently in treatment for psychosis or bipolar disorder Participants must report either that they have: smoked at least 5 cpd for the past 6 months and not used EC within the last 3 months ("exclusive smokers") or used nicotine‐containing EC at least once a week for the past month and have smoked at least 5 cpd for the last 3 months ("dual users")
Interventions	"We will conduct a 2‐year longitudinal cohort study comprising participants who smoke exclusively CCs (n = 175) and dual users of e‐cigs and CCs (n = 275)"
Outcomes	"We will use state‐of‐the‐art ecological momentary assessments to determine: 1) dynamic patterns of e‐cig and CC use and related outcomes (e.g. dependence, withdrawal symptoms, CC quit attempts and quitting success); 2) episodic (affective, contextual, social) and stable person‐factor (lifestyle factors, demographics) variables that covary meaningfully with e‐cig and CC use and related outcomes; 3) biomarkers of tobacco and carcinogen exposure as well as other health‐related outcomes (e.g. reduced pulmonary function)."
Starting date	September 2015
Contact information	PI Megan Piper
Notes