Summary of findings 1. Antidepressant compared to placebo for the treatment of functional abdominal pain disorders in children and adolescents.
| Antidepressant compared to placebo for the treatment of functional abdominal pain disorders in children and adolescents | ||||||
| Patient or population: Children and adolescents with functional abdominal pain disorder Setting: Outpatient Intervention: Antidepressant Comparison: Placebo | ||||||
| Outcomes | Anticipated absolute effects* (95% CI) | Relative effect (95% CI) | № of participants (studies) | Certainty of the evidence (GRADE) | Comments | |
| Risk with placebo | Risk with antidepressant | |||||
| Treatment success | Study population | RR 1.17 (0.87 to 1.56) | 205 (2 RCTs) | ⊕⊕⊝⊝ LOWa | ‐ | |
| 440 per 1000 | 515 per 1000 (383 to 686) | |||||
| Withdrawals due to adverse events | Study population | RR 3.17 (0.65 to 15.33) | 238 (3 RCTs) | ⊕⊕⊝⊝ LOWa | ‐ | |
| 17 per 1000 | 54 per 1000 (11 to 262) | |||||
| *The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: Confidence interval; RR: Risk ratio; | ||||||
| GRADE Working Group grades of evidence High certainty: We are very confident that the true effect lies close to that of the estimate of the effect Moderate certainty: We are moderately confident in the effect estimate: The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different Low certainty: Our confidence in the effect estimate is limited: The true effect may be substantially different from the estimate of the effect Very low certainty: We have very little confidence in the effect estimate: The true effect is likely to be substantially different from the estimate of effect | ||||||
aDowngraded two levels due to significant imprecision for extremely sparse data.