Source	Search strategy	Hits retrieved
CENTRAL	#1 MESH DESCRIPTOR Arterial Occlusive Diseases 874 #2 MESH DESCRIPTOR Arteriolosclerosis 0 #3 MESH DESCRIPTOR Arteriosclerosis 1009 #4 MESH DESCRIPTOR Arteriosclerosis Obliterans 87 #5 MESH DESCRIPTOR Femoral Artery EXPLODE ALL TREES 958 #6 MESH DESCRIPTOR Iliac Artery EXPLODE ALL TREES 161 #7 MESH DESCRIPTOR Intermittent Claudication 898 #8 MESH DESCRIPTOR Ischemia EXPLODE ALL TREES WITH QUALIFIERS DT,ET,MO,SU,TH 613 #9 MESH DESCRIPTOR Leg EXPLODE ALL TREES 2852 #10 MESH DESCRIPTOR Peripheral Vascular Diseases EXPLODE ALL TREES 3110 #11 MESH DESCRIPTOR Popliteal Artery 328 #12 MESH DESCRIPTOR Tibial Arteries 40 #13 arteriosclero*:TI,AB,KY 2054 #14 arteriopathic:TI,AB,KY 7 #15 claudic*:TI,AB,KY 2408 #16 CLI:TI,AB,KY 635 #17 dysvascular*:TI,AB,KY 28 #18 isch*:TI,AB,KY 43093 #19 PVD:TI,AB,KY 279 #20 PAOD:TI,AB,KY 162 #21 (peripheral adj3 dis*):TI,AB,KY 6550 #22 ((("lower extrem*" or arter* or crural or femdist* or femoral or fempop* or iliac or infrainquinal or infrapopliteal or inguinal or limb or peripher* or popliteal or tibial or vascular or vein* or veno*) adj3 (block* or harden* or lesio* or obliter* or obstruct* or occlus* or reocclus* or re‐occlus* or restenos* or steno* or stiffen*))):TI,AB,KY 15770 #23 #1 OR #2 OR #3 OR #4 OR #5 OR #6 OR #7 OR #8 OR #9 OR #10 OR #11 OR #12 OR #13 OR #14 OR #15 OR #16 OR #17 OR #18 OR #19 OR #20 OR #21 OR #22 65776 #24 MESH DESCRIPTOR Pentoxifylline EXPLODE ALL TREES 554 #25 (pentox* or oxypent*):TI,AB,KY 1273 #26 MESH DESCRIPTOR Phosphodiesterase Inhibitors EXPLODE ALL TREES 6985 #27 (phosphodiesterase adj2 inhibitor*):TI,AB,KY 2325 #28 BL‐191:TI,AB,KY 5 #29 #24 OR #25 OR #26 OR #27 OR #28 8675 #30 #23 AND #29 906 #31 01/01/2015 TO 28/01/2020:CD 822173 #32 #30 AND #31 214	214
Clinicaltrials.gov	intermittent claudication OR Peripheral Vascular Diseases | Pentoxifylline OR Phosphodiesterase Inhibitors OR oxypent*	12
ICTRP Search Portal	intermittent claudication OR Peripheral Vascular Diseases | Pentoxifylline OR Phosphodiesterase Inhibitors OR oxypent*	0
MEDLINE (Ovid MEDLINE Epub Ahead of Print, In‐Process & Other Non‐Indexed Citations, Ovid MEDLINE Daily and Ovid MEDLINE) 1946 to present 2017 onwards	1 Arterial Occlusive Diseases/ 2 Arteriolosclerosis/ 3 Arteriosclerosis/ 4 Arteriosclerosis Obliterans/ 5 Femoral Artery/ 6 Iliac Artery/ 7 Intermittent Claudication/ 8 Ischemia/dt, et, mo, su, th [Drug Therapy, Etiology, Mortality, Surgery, Therapy] 9 Leg/bs [Blood Supply] 10 exp Peripheral Vascular Diseases/ 11 Popliteal Artery/ 12 Tibial Arteries/ 13 arteriosclero*.ti,ab. 14 arteriopathic.ti,ab. 15 claudic*.ti,ab. 16 CLI.ti,ab. 17 dysvascular*.ti,ab. 18 isch*.ti,ab. 19 PVD.ti,ab. 20 PAOD.ti,ab. 21 (peripheral adj3 dis*).ti,ab. 22 (("lower extrem*" or arter* or crural or femdist* or femoral or fempop* or iliac or infrainquinal or infrapopliteal or inguinal or limb or peripher* or popliteal or tibial or vascular or vein* or veno*) adj3 (block* or harden* or lesio* or obliter* or obstruct* or occlus* or reocclus* or re‐occlus* or restenos* or steno* or stiffen*)).ti,ab. 23 or/1‐22 24 exp Pentoxifylline/ 25 (pentox* or oxypent*).ti,ab. 26 exp Phosphodiesterase Inhibitors/ 27 (phosphodiesterase adj2 inhibitor*).ti,ab. 28 BL‐191.ti,ab. 29 or/24‐28 30 23 and 29 31 randomized controlled trial.pt. 32 controlled clinical trial.pt. 33 randomized.ab. 34 placebo.ab. 35 drug therapy.fs. 36 randomly.ab. 37 trial.ab. 38 groups.ab. 39 or/31‐38 40 exp animals/ not humans.sh. 41 39 not 40 42 30 and 41 43 (2015* or 2016* or 2017* or 2018* or 2019* or 2020*).ed. 44 30 and 43
Embase 1974 to present 2017 onwards	1 peripheral occlusive artery disease/ 2 arteriolosclerosis/ 3 arteriosclerosis/ 4 femoral artery/ 5 iliac artery/ 6 intermittent claudication/ 7 ischemia/dt, et, su, th [Drug Therapy, Etiology, Surgery, Therapy] 8 exp peripheral vascular disease/ 9 popliteal artery/ 10 tibial artery/ 11 arteriosclero*.ti,ab. 12 arteriopathic.ti,ab. 13 claudic*.ti,ab. 14 CLI.ti,ab. 15 dysvascular*.ti,ab. 16 isch*.ti,ab. 17 PVD.ti,ab. 18 PAOD.ti,ab. 19 (peripheral adj3 dis*).ti,ab. 20 (("lower extrem*" or arter* or crural or femdist* or femoral or fempop* or iliac or infrainquinal or infrapopliteal or inguinal or limb or peripher* or popliteal or tibial or vascular or vein* or veno*) adj3 (block* or harden* or lesio* or obliter* or obstruct* or occlus* or reocclus* or re‐occlus* or restenos* or steno* or stiffen*)).ti,ab. 21 or/1‐20 22 exp pentoxifylline/ 23 (pentox* or oxypent*).ti,ab. 24 exp phosphodiesterase inhibitor/ 25 (phosphodiesterase adj2 inhibitor*).ti,ab. 26 BL‐191.ti,ab. 27 or/22‐26 28 21 and 27 29 randomized controlled trial/ 30 controlled clinical trial/ 31 random$.ti,ab. 32 randomization/ 33 intermethod comparison/ 34 placebo.ti,ab. 35 (compare or compared or comparison).ti. 36 ((evaluated or evaluate or evaluating or assessed or assess) and (compare or compared or comparing or comparison)).ab. 37 (open adj label).ti,ab. 38 ((double or single or doubly or singly) adj (blind or blinded or blindly)).ti,ab. 39 double blind procedure/ 40 parallel group$1.ti,ab. 41 (crossover or cross over).ti,ab. 42 ((assign$ or match or matched or allocation) adj5 (alternate or group$1 or intervention$1 or patient$1 or subject$1 or participant$1)).ti,ab. 43 (assigned or allocated).ti,ab. 44 (controlled adj7 (study or design or trial)).ti,ab. 45 (volunteer or volunteers).ti,ab. 46 trial.ti. 47 or/29‐46 48 28 and 47 49 (2015* or 2016* or 2017* or 2018* or 2019* or 2020*).dc. 50 48 and 49	1077
CINAHL 2017 onwards	S46 S44 AND S45 S45 EM 2015 OR EM 2016 OR EM 2017 OR EM 2018 OR EM 2019 OR EM 2020 S44 S28 AND S43 S43 S29 OR S30 OR S31 OR S32 OR S33 OR S34 OR S35 OR S36 OR S37 OR S38 OR S39 OR S40 OR S41 OR S42 S42 MH "Random Assignment" S41 MH "Triple‐Blind Studies" S40 MH "Double‐Blind Studies" S39 MH "Single‐Blind Studies" S38 MH "Crossover Design" S37 MH "Factorial Design" S36 MH "Placebos" S35 MH "Clinical Trials" S34 TX "multi‐centre study" OR "multi‐center study" OR "multicentre study" OR "multicenter study" OR "multi‐site study" S33 TX crossover OR "cross‐over" S32 AB placebo* S31 TX random* S30 TX trial* S29 TX "latin square" S28 S21 AND S27 S27 S22 OR S23 OR S24 OR S25 OR S26 S26 TX BL‐191 S25 TX phosphodiesterase N2 inhibitor* S24 (MH "Phosphodiesterase Inhibitors+") S23 TX pentox* or oxypent* S22 (MH "Pentoxifylline") S21 S1 OR S2 OR S3 OR S4 OR S5 OR S6 OR S7 OR S8 OR S9 OR S10 OR S11 OR S12 OR S13 OR S14 OR S15 OR S16 OR S17 OR S18 OR S19 OR S20 S20 TX peripheral N3 dis* S19 TX (("lower extrem*" or arter* or crural or femdist* or femoral or fempop* or iliac or infrainquinal or infrapopliteal or inguinal or limb or peripher* or popliteal or tibial or vascular or vein* or veno*) N3 (block* or harden* or lesio* or obliter* or obstruct* or occlus* or reocclus* or re‐occlus* or restenos* or steno* or stiffen*)) S18 TX PAOD S17 TX PVD S16 TX isch* S15 TX dysvascular* S14 TX CLI S13 TX claudic* S12 TX arteriopathic S11 TX arteriosclero* S10 (MH "Tibial Arteries") S9 (MH "Popliteal Artery") S8 (MH "Peripheral Vascular Diseases+") S7 (MH "Leg/BS") S6 (MH "Ischemia/DT/ET/MO/SU/TH") S5 (MH "Intermittent Claudication") S4 (MH "Iliac Artery") S3 (MH "Femoral Artery") S2 (MH "Arteriosclerosis") S1 (MH "Arterial Occlusive Diseases+")	27