Chacon‐Quevedo 1994.

Study characteristics
Methods	Study design: double‐blind, randomised Country: Spain Setting: single centre Intention‐to‐treat: not mentioned
Participants	Number of participants randomly assigned: 45 (15 in each group) Number of participants analysed: 45 Exclusions postrandomisation: 0 Losses to follow‐up: 0 Age (mean): 61 (SD 8) years Sex: all men Inclusion criteria: PAD Fontaine stage II Exclusion criteria: not mentioned
Interventions	Treatment: pentoxifylline, 1200 mg daily Control: Buflomedil, 600 mg daily Nifedipine, 60 mg daily Duration: 90 days
Outcomes	Primary: mean PFWD, TWD Secondary: ABI
Notes	Treadmill protocol: 3 km/h at 10% inclination Mean PFWD and TWD expressed in metres only
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Quote: "patients were divided randomly into three treatment groups." Comment: no other information provided.
Allocation concealment (selection bias)	Unclear risk	Not mentioned.
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Insufficient information provided to permit judgement.
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Insufficient information provided to permit judgement.
Incomplete outcome data (attrition bias) All outcomes	Low risk	No incomplete outcome data.
Selective reporting (reporting bias)	Unclear risk	Insufficient information provided to permit judgement.
Other bias	Unclear risk	Insufficient information provided to permit judgement.