Figure 3.

Relationship between the molecular pathway of genes linked to aggressive PRL tumor phenotype and genes located in the deleted region of chromosome 11p in aggressive prolactin (PRL) tumors. Candidate genes located on the deleted 11p region and linked to the molecular pathway associated with aggressive tumors are indicated with blue dots. Genes in red are those found to be upregulated by transcriptomic comparison in aggressive tumors compared with nonaggressive tumors. The green color represents genes in the 11p deleted region found to be downregulated by transcriptomic analysis. The signaling pathway has been deciphered using Ingenuity Pathway Analysis software.