Figure 6.

Proposed model of prolactin (PRL) tumor progression. The structural alterations of genomes seem to be an early event in PRL tumor development. Discrete and sparse alterations led to a nonaggressive phenotype. Specific loss of the p arm of chromosome 11 impacts the gene expression, leading to deregulation of cell growth and inducing the aggressive phenotype. Afterward, loss of the q arm of chromosome 11 occurs in the aggressive tumor group and may contribute to malignant phenotype of PRL tumors.