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. 2011 Jan 27;21(2):150–162. doi: 10.1111/j.1750-3639.2010.00431.x

Figure 7.

Figure 7

Brain‐derived neurotrophic factor (BDNF) activation of casein kinase II (CK2) is independent of BDNF activation of ERK1/2 and PI3‐K. A. Effects of prior infusion of PD98059 on BDNF‐induced CK2 enzyme activity (upper panel) and pERK1/2 as well as ERK1/2 levels (lower panel) in CA1 area. Animals received BDNF infusion alone (0.4 µg) or in combination with the ERK1/2 inhibitor PD98059 (1.4 µg). PD98059 was given 15 minutes before BDNF infusion and animals were sacrificed 1 h after BDNF infusion. B. Effects of prior infusion of LY294002 on BDNF‐induced CK2 enzyme activity (upper panel) and pS308Akt as well as Akt levels (lower panel) in CA1 area. Animals received BDNF infusion alone (0.4 µg) or in combination with the PI3‐K inhibitor LY294002 (1.5 µg). LY294002 was given 15 mintues before BDNF infusion and animals were sacrificed 1 h after BDNF infusion. N = 5 each group. Data are expressed as mean ± standard error of the mean. Statistical significance was evaluated by one‐way analysis of variance followed by Newman–Keul's comparison. *P < 0.05, a: compared with the corresponding control group.