Table 3.

Classification of demyelinating lesions according to aquaporin‐4 and glial fibrillary acid protein immunostaining and Klüver‐Barrera staining. Abbreviations: AQP4 = aquaporin‐4; GFAP = glial fibrillary acidic protein; KB = Klüver‐Barrera staining.

Lesion pattern	Extents of AQP4 and myelin loss	GFAP expression
Pattern A	AQP4 loss or decrease > myelin loss	(+)
Pattern B	AQP4 loss or decrease = myelin loss	(+)
Pattern C	AQP4 loss or decrease < myelin loss	(+)
Pattern D	AQP4 totally preserved in areas of myelin loss	(+)
Pattern N	necrosis or cavity formation	(−)