Table 4.

Summary of aquaporin‐4 immunoreactivity patterns in demyelinating lesions in cases with neuromyelitis optica (NMO) or NMO spectrum disorders. Abbreviations: AQP4 = aquaporin‐4; NMO = neuromyelitis optica; NMOSD = neuromyelitis optica spectrum disorder; N.A. = specimen not available.

Autopsy	Stage	Cerebrum	Brainstem	Cerebellum	Spinal cord	Optic nerve
Preferential AQP4 loss or decrease
NMO‐2	Active	A (1)	A&N (1)	N.A.	B&N (1)	N.A.
	Chronic active	B&N (1), C&N (1)			A&N (3), B&N (1)
	Chronic inactive	C (2)			C&N (1)
NMO‐3	Active	B&N (1)				A&N (1)
	Chronic active	B&N (1), C&N (1)	A (1)		A&N (3)	A&N (1)
	Chronic inactive	C&N (3)
NMO‐4	Active	A (1), A&N (3), B (1), B&N (1)	A&N (2), B&N (1)	B (2)	B&N (1)	D (1)
	Chronic active	B&N (1)	B (2)		A&N (1), B&N (1), C&N (1)
	Chronic inactive	D (1)
NMO‐7	Active		A (3), B (1)		A&N (2)
	Chronic active	C (3)	A (3), B (1), C (1), C&N (1)
	Chronic inactive	C (1), D (2)	C&N (2)			D&N (1)
NMO‐10	Active	A (1), A&N (1), N (1)				N.A.
	Chronic active	B (2), B&N (1), C&N (1)	C&N (1)		A&N (1), C&N (1)
	Chronic inactive	D (1), N (1)
NMOSD	Active				A&N (1), B&N (1), N (1)
	Chronic active				B&N (1)
	Chronic inactive					D (1)
Preserved AQP4 expression
NMO‐1	Active	D&N (1)	N (2)
	Chronic active		D (1)		D (1)	D (1)
	Chronic inactive	D&N (1)
NMO‐5	Active	D&N (1), D (3)
	Chronic active	D (5), D&N (4)	D&N (1), D (2)	D (2)
	Chronic inactive	D (3)	D&N (1)		D&N (1)	D (1)
NMO‐6	Active	D (1)
	Chronic active	D (5), D&N (2)	D&N (1)	D (1)
	Chronic inactive	D (1)	D&N (1)		D (1), D&N (1)	D&N (1)
NMO‐8	Chronic active	D (1), D&N (5)	D&N (1)		D&N (1)	D (1)
	Chronic inactive	D (1), D&N (1)	D (2), N (1)			N (1)
NMO‐9	Active				D&N (1), N (2)	D (1)
	Chronic active				D&N (1)

Blank cell = No lesions.