Table 5.
Summary of aquaporin‐4 immunoreactivity patterns in demyelinating lesions in cases with multiple sclerosis. Abbreviations: AQP4 = aquaporin‐4; MS = multiple sclerosis.
| Autopsy | Stage | Cerebrum | Brainstem | Cerebellum | Spinal cord | Optic nerve |
|---|---|---|---|---|---|---|
| Preferential AQP4 loss or decrease | ||||||
| MS‐3 | Active | A&N (1), B (3), B&N (1), N (1) | A&N (2), N (2) | |||
| Chronic active | B (2) | |||||
| Chronic inactive | C (1) | |||||
| MS‐4 | Active | A (1), B (3) | ||||
| Chronic active | B (1) | A &N (3), A (1) | C (1) | |||
| Preserved AQP4 expression | ||||||
| MS‐1 | Active | N (3) | ||||
| Chronic active | D&N (1) | |||||
| Chronic inactive | D (1), D&N (2) | |||||
| MS‐2 | Active | D (1), D&N (1) | D (1) | |||
| Chronic active | D (2) | D (1) | ||||
| MS‐5 | Active | D (2) | D (1) | D (1) | ||
| Chronic active | D (1) | D (1) | ||||
| Chronic inactive | D (4), D&N (3) | D (1) | D (1) | |||
Blank cell = no lesions.