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Pedigrees of families with CCM1, CCM2 and CCM3 mutations. Pedigrees are arranged as reported in Table 2; no pedigrees were available for probands 56 and 28. 
= proband; 
= affected; 
= asymptomatic; 
= obligate carrier; 
= not known to be affected; M = mutation; WT = no mutation; 
= deceased.
