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. 2020 Sep 8;2020(9):CD005291. doi: 10.1002/14651858.CD005291.pub3

Comparison 1. IVF with PGT‐A versus IVF without PGT‐A with the use of genome‐wide analyses.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1.1 Cumulative live birth rate after the first treatment cycle, per woman randomised 1   Odds Ratio (M‐H, Random, 95% CI) Totals not selected
1.1.1 Polar body biopsy 1   Odds Ratio (M‐H, Random, 95% CI) Totals not selected
1.2 Live birth rate after the first embryo transfer per woman randomised 2   Odds Ratio (M‐H, Fixed, 95% CI) Subtotals only
1.2.1 Polar body biopsy 1 396 Odds Ratio (M‐H, Fixed, 95% CI) 1.10 [0.68, 1.79]
1.2.2 Blastocyst stage biopsy 1 661 Odds Ratio (M‐H, Fixed, 95% CI) 0.93 [0.69, 1.27]
1.3 Miscarriage rate per woman randomised 2   Odds Ratio (M‐H, Fixed, 95% CI) Subtotals only
1.3.1 Polar body biopsy 1 396 Odds Ratio (M‐H, Fixed, 95% CI) 0.45 [0.23, 0.88]
1.3.2 Blastocyst stage biopsy 1 661 Odds Ratio (M‐H, Fixed, 95% CI) 0.89 [0.52, 1.54]
1.4 Miscarriage rate per clinical pregnancy 1   Odds Ratio (M‐H, Fixed, 95% CI) Subtotals only
1.4.1 Polar body biopsy 1 136 Odds Ratio (M‐H, Fixed, 95% CI) 0.47 [0.22, 1.00]
1.5 Clinical pregnancy per woman randomised 1   Odds Ratio (M‐H, Random, 95% CI) Totals not selected
1.5.1 Polar body biopsy 1   Odds Ratio (M‐H, Random, 95% CI) Totals not selected
1.6 Multiple pregnancy per woman randomised 1 396 Odds Ratio (M‐H, Fixed, 95% CI) 0.53 [0.20, 1.37]
1.6.1 Polar body biopsy 1 396 Odds Ratio (M‐H, Fixed, 95% CI) 0.53 [0.20, 1.37]
1.7 Multiple pregnancy rate per live birth 1 95 Odds Ratio (M‐H, Fixed, 95% CI) 0.45 [0.16, 1.26]
1.7.1 Polar body biopsy 1 95 Odds Ratio (M‐H, Fixed, 95% CI) 0.45 [0.16, 1.26]
1.8 Proportion of women reaching embryo transfer per woman randomised 2   Odds Ratio (M‐H, Fixed, 95% CI) Subtotals only
1.8.1 Polar body biopsy 1 396 Odds Ratio (M‐H, Fixed, 95% CI) 0.31 [0.18, 0.54]
1.8.2 Blastocyst stage biopsy 1 661 Odds Ratio (M‐H, Fixed, 95% CI) 0.28 [0.16, 0.49]
1.9 Mean number of embryos transferred per transfer 2   Mean Difference (IV, Fixed, 95% CI) Subtotals only
1.9.1 Polar body biopsy 1 426 Mean Difference (IV, Fixed, 95% CI) ‐0.40 [‐0.49, ‐0.31]
1.9.2 Blastocyst stage biopsy 1 587 Mean Difference (IV, Fixed, 95% CI) Not estimable