Schoolcraft 2009.

Study characteristics
Methods	Study design: randomised controlled trial Duration and location of the trial: between May 2002 and March 2004, private fertility clinic, New Jersey, USA Sample size: not performed 62 women randomised
Participants	Inclusion criteria: women 35 years of age or older with at least 5 embryos consisting of at least 6 cells and less than 15% fragmentation on day 3 Exclusion criteria: ‐
Interventions	Type of biopsy: cleavage stage biopsy Genetic analysis: genetic analysis with FISH analysis
Outcomes	live birth rate Miscarriage rate Proportion of women reaching embryo transfer
Notes	Treatment procedure: IVF and ICSI Embryo transfer policy: maximum number of embryos transferred not reported
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Quote: "eligible couples were assigned randomly by a computer‐generated random number table"
Allocation concealment (selection bias)	Unclear risk	Judgement comment: concealment of allocation not reported
Blinding of participants and personnel (performance bias) All outcomes	High risk	Judgement comment: not blinded
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Judgement comment: non‐blinding not likely to affect objective outcomes
Incomplete outcome data (attrition bias) All outcomes	Low risk	Judgement comment: all women randomised were analysed
Selective reporting (reporting bias)	Low risk	Judgement comment: a priori outcomes reported
Other bias	Low risk	Judgement comment: no suggestion of other bias Funding: unclear whether this was a sponsored trial