| Study name |
Effects of PGS 2.0 in Patients With Unexplained RPL |
| Methods |
Randomised controlled trial |
| Participants |
Sample size: 710
Inclusion criteria: couple has experienced 2 or more failed pregnancies; karyotypes of both husband and wife are normal (polymorphic chromosomes are considered normal either); women age ≥ 20 and < 38 years old
Exclusion criteria:
The wife has a history of the following diseases: a, the history of thyroid disease; b, the history of adrenal diseases; c, the history of sexually transmitted diseases; d, the history of hereditary diseases; e, the history of mental and psychological disorders. The wife has the following uterine abnormalities: a, uterine malformations (uterus unicorns and duplex uterus), untreated septate uterus, adenomyoma, submucous uterine fibroids, endometrial polyps, or intrauterine adhesions (including the history of intrauterine adhesions). The wife has a medical condition that contraindicates ART or pregnancy, including poorly controlled type I or type II diabetes; undiagnosed liver and renal disease or liver and renal insufficiency (based on blood test); deep vein thrombosis; pulmonary embolism; history of cerebrovascular accident; uncontrolled hypertension; cardiac disease; carcinoma; severe anaemia; suspicious or undiagnosed vaginal bleeding.
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| Interventions |
Blastocysts are selected by PGS 2.0 (NGS based), and only euploid embryos will be transferred. |
| Outcomes |
Primary outcome: cumulative live birth rate |
| Starting date |
6 February 2018 |
| Contact information |
Caixia Lei, MD
Shanghai Ji Ai Genetics & IVF Institute, Obstetrics and Gynecology Hospital, Fudan University
Telephone: 86‐18917958213
Email: green3318@163.com |
| Notes |
First posted 11 July 2017, last updated 6 February 2018 |
