NCT03371745.

Study name	The PrISICE Clinical Trial (Pre‐Implantation Screening and Investigation on the Cryopreservation of Embryos) (PrISICE)
Methods	Randomised controlled trial
Participants	Sample size: 1539 Inclusion criteria: 18 to 42 years
Interventions	Group 1: PGS‐FET group: deferred transfer of day 5/6/7 (blastocyst stage) embryos cryopreserved following trophectoderm biopsy Group 2: "freeze‐only" (FET) group: deferred transfer of frozen/thawed embryos without biopsy Group 3: "fresh" ET group: immediate transfer of "fresh" embryos in the stimulation cycle
Outcomes	Primary outcome: live birth
Starting date	August 2018
Contact information	Rebecca Wong Yale University Telephone 415‐353‐4305 Email: rebecca.wong@ucsf.edu or Nik Lenhart Telephone 415‐885‐3598 Email: lenhartn@obgyn.ucsf.edu
Notes	First posted 13 December 2017, last updated 15 October 2019

AMH: Anti‐Mullerian Hormone

ART: Assisted reproductive technology

ASRM: American Society for Reproductive Medicine

BMI: Body mass index

CCS: Comprehensive Chromosome Screening

ESHRE: European Society of Human Reproduction and Embryology

E2: Estradiol

FET: Frozen embryo transfer

FSH: Follicle stimulating hormone

GnRH: gonadotropin‐releasing hormone

HSG: hysterosalpingogram

ICSI: intracytoplasmic sperm injection

IU: International United

IVF: in vitro fertilisation

LH: Luteinizing hormone

NGS: Next Generation Sequencing

PGD: Preimplantation genetic diagnosis

PGS: Preimplantation genetic screening

RPL: recurrent pregnancy loss

WHO; World Health Organisation