Segura‐Castillo 2005.

Study characteristics
Methods	Study design: prospective randomised controlled trial Randomisation technique: random allocation Allocation concealment: adequate Inclusion criteria: well explained Exclusion criteria: well explained Lost to follow‐up: not reported Baseline variables: matching between both limbs of the trial Intention‐to‐treat analysis: not reported Sample size calculations (power of the study): not reported
Participants	Country: Mexico Number of participants: FG: 22 and NFG: 23 Mean age (years): FG 48.36 ± 8.9; NFG 52.87 ± 9.74
Interventions	FG: Quixil TM was applied under skin flaps following breast and axillary surgery Types of surgical intervention: modified radical mastectomy axillary dissection Confounding interventions: none
Outcomes	Primary: seroma incidence Secondary: wound infection length of seroma drainage in days postoperative complications
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Random numbers
Allocation concealment (selection bias)	Low risk	Reported
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Adequate
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Adequate
Incomplete outcome data (attrition bias) All outcomes	High risk	Not reported
Selective reporting (reporting bias)	Low risk	No
Other bias	Low risk	Inclusion, exclusion criteria, ethics approval and conflict of interest declaration was adequately reported