Summary of findings 2. Risk of postoperative infectious complications: 5‐ASA compared to control.
| Risk of postoperative infectious complications: 5‐ASA compared to control | |||||
| Patient or population: inflammatory bowel disease Setting: Intervention: 5‐ASA Comparison: control | |||||
| Outcomes | Anticipated absolute effects* (95% CI) | Relative effect (95% CI) | № of participants (studies) | Certainty of the evidence (GRADE) | |
| Risk with control | Risk with 5‐ASA | ||||
| Overall infectious complications within 30 days of surgery | Study population | OR 0.76 (0.51 to 1.14) | 6 observational studies | ⊕⊝⊝⊝ VERY LOW 2 3 | |
| 148 per 1,000 1 | 116 per 1,000 (81 to 165) | ||||
| Overall infectious complications within 30 days of surgery (Adjusted Analysis) 1 | Study population | ‐ | 0 studies | ‐ | |
| ‐ | ‐ | ||||
| Overall infectious complications within 30 days of surgery (Unadjusted Analysis) | Study population | OR 0.76 (0.51 to 1.14) | 6 observational studies | ⊕⊝⊝⊝ VERY LOW 2 3 | |
| 148 per 1,000 | 116 per 1,000 (81 to 165) | ||||
| Incisional infections and wound dehiscence within 30 days of surgery | Study population | OR 0.53 (0.30 to 0.95) | 1 study | ‐ | |
| 265 per 1,000 | 160 per 1,000 (98 to 255) | ||||
| Intra‐abdominal infectious complications within 30 days of surgery | Study population | OR 0.77 (0.45 to 1.33) | 3 observational studies | ⊕⊝⊝⊝ VERY LOW 2 3 | |
| 108 per 1,000 | 86 per 1,000 (52 to 139) | ||||
| Extra‐abdominal infections within 30 days of surgery 1 | Study population | ‐ | 0 studies | ‐ | |
| ‐ | ‐ | ||||
| *The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: Confidence interval; RR: Risk ratio; OR: Odds ratio; | |||||
| GRADE Working Group grades of evidence High certainty: We are very confident that the true effect lies close to that of the estimate of the effect Moderate certainty: We are moderately confident in the effect estimate: The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different Low certainty: Our confidence in the effect estimate is limited: The true effect may be substantially different from the estimate of the effect Very low certainty: We have very little confidence in the effect estimate: The true effect is likely to be substantially different from the estimate of effect | |||||
1 Analysis was not performed as no appropriate studies were identified
2 All studies were considered very high risk of bias according to the Newcastle Ottawa Scale
3 Wide confidence interval
4 Unable to assess GRADE as only 1 study was identified