Summary of findings 5. Risk of postoperative infectious complications: anti‐integrin agents compared to control.
| Risk of postoperative infectious complications: anti‐integrin agents compared to control | |||||
| Patient or population: inflammatory bowel disease Setting: Intervention: Anti‐integrin agents Comparison: control | |||||
| Outcomes | Anticipated absolute effects* (95% CI) | Relative effect (95% CI) | № of participants (studies) | Certainty of the evidence (GRADE) | |
| Risk with control | Risk with Anti‐integrin agents | ||||
| Overall infectious complications within 30 days of surgery | Study population | OR 1.11 (0.76 to 1.62) | 9 observational studies | ⊕⊝⊝⊝ VERY LOW 1 2 | |
| 136 per 1,000 | 149 per 1,000 (107 to 203) | ||||
| Overall infectious complications within 30 days of surgery (Adjusted Analysis) | Study population | OR 1.04 (0.79 to 1.36) | 2 observational studies | ⊕⊕⊝⊝ LOW | |
| 136 per 1,000 | 141 per 1,000 (111 to 176) | ||||
| Overall infectious complications within 30 days of surgery (Unadjusted Analysis) | Study population | OR 1.06 (0.54 to 2.10) | 7 observational studies | ⊕⊝⊝⊝ VERY LOW 1 2 | |
| 136 per 1,000 | 143 per 1,000 (78 to 248) | ||||
| Incisional infections and wound dehiscence within 30 days of surgery | Study population | OR 1.64 (0.77 to 3.50) | 6 observational studies | ⊕⊝⊝⊝ VERY LOW 1 2 3 | |
| 20 per 1,000 | 32 per 1,000 (15 to 67) | ||||
| Intra‐abdominal infectious complications within 30 days of surgery | Study population | OR 0.40 (0.14 to 1.20) | 5 observational studies | ⊕⊝⊝⊝ VERY LOW 1 2 | |
| 88 per 1,000 | 37 per 1,000 (13 to 104) | ||||
| Extra‐abdominal infections within 30 days of surgery | Study population | OR 1.15 (0.43 to 3.08) | 5 observational studies | ⊕⊝⊝⊝ VERY LOW 1 2 3 | |
| 28 per 1,000 | 32 per 1,000 (12 to 81) | ||||
| *The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: Confidence interval; RR: Risk ratio; OR: Odds ratio; | |||||
| GRADE Working Group grades of evidence High certainty: We are very confident that the true effect lies close to that of the estimate of the effect Moderate certainty: We are moderately confident in the effect estimate: The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different Low certainty: Our confidence in the effect estimate is limited: The true effect may be substantially different from the estimate of the effect Very low certainty: We have very little confidence in the effect estimate: The true effect is likely to be substantially different from the estimate of effect | |||||
1 Many studies did not performed adjusted analyses and were considered to have a high risk of bias according to the Newcastle Ottawa Scale
2 Wide confidence interval
3 High degree of heterogeneity