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. 2020 Oct 24;2020(10):CD013256. doi: 10.1002/14651858.CD013256.pub2

Comparison 4. Anti‐TNF‐α agents versus control.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
4.1 Postoperative infection within 30 days of surgery 54   Odds Ratio (IV, Random, 95% CI) Subtotals only
4.1.1 Adjusted Analysis 17   Odds Ratio (IV, Random, 95% CI) 1.60 [1.20, 2.13]
4.1.2 Unadjusted Analysis 37   Odds Ratio (IV, Random, 95% CI) 1.14 [0.96, 1.36]
4.2 Postoperative infection within 30 days of surgery: subgroup UC vs CD 43   Odds Ratio (IV, Random, 95% CI) 1.26 [1.03, 1.53]
4.2.1 Ulcerative colitis 17   Odds Ratio (IV, Random, 95% CI) 1.04 [0.79, 1.36]
4.2.2 Crohn's disease 27   Odds Ratio (IV, Random, 95% CI) 1.43 [1.09, 1.87]
4.3 Postoperative infection within 30 days of surgery: subgroup biologics < 8 weeks before surgery vs > 8 weeks before surgery 51   Odds Ratio (IV, Random, 95% CI) 1.25 [1.08, 1.46]
4.3.1 < 8 weeks before surgery 17   Odds Ratio (IV, Random, 95% CI) 1.44 [1.08, 1.94]
4.3.2 > 8 weeks before surgery 34   Odds Ratio (IV, Random, 95% CI) 1.18 [0.99, 1.40]
4.4 Incisional infections and wound dehiscence 24   Odds Ratio (IV, Random, 95% CI) 1.18 [0.83, 1.68]
4.5 Intra‐abdominal infectious complications 39   Odds Ratio (IV, Random, 95% CI) 1.38 [1.04, 1.82]
4.6 Extra‐abdominal infections 13   Odds Ratio (IV, Random, 95% CI) 1.34 [0.96, 1.87]
4.7 Postoperative infection within 30 days of surgery: sensitivity excluding very high risk of bias 16   Odds Ratio (IV, Random, 95% CI) 1.67 [1.31, 2.13]
4.8 Postoperative infection within 30 days of surgery: sensitivity exclude abstract 47   Odds Ratio (IV, Random, 95% CI) 1.26 [1.07, 1.48]
4.9 Postoperative infection within 30 days of surgery: sensitivity exclude surgery for abscess 37   Odds Ratio (IV, Random, 95% CI) 1.31 [1.10, 1.56]
4.9.1 Adjusted Analysis 8   Odds Ratio (IV, Random, 95% CI) 1.61 [0.98, 2.65]
4.9.2 Unadjusted Analysis 29   Odds Ratio (IV, Random, 95% CI) 1.24 [1.03, 1.50]
4.10 Postoperative infection within 30 days of surgery: sensitivity excluding sum of infection studies 46   Odds Ratio (IV, Random, 95% CI) 1.22 [1.02, 1.45]
4.10.1 Adjusted Analysis 17   Odds Ratio (IV, Random, 95% CI) 1.60 [1.20, 2.13]
4.10.2 Unadjusted Analysis 29   Odds Ratio (IV, Random, 95% CI) 1.01 [0.82, 1.24]