Fumery 2017.
Study characteristics | ||
Methods | Prospective, multicenter (9 institutions) cohort. Study period: 2010 to 2014 | |
Participants | Country: France. CD patients who underwent ileocecal resection. Pregnant patients and those who had surgery for dysplasia were excluded | |
Interventions | 1. Preoperative steroids (n= 45) 2. Preoperative anti‐TNF therapy (n= 93) within 4 weeks of surgery 3. No preoperative steroid (n= 164) 4. No preoperative anti‐TNF therapy (n= 165) |
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Outcomes | Abdominal infections and extaabdominal infections within 30 days of surgery | |
Notes | NOS very high risk of bias overall | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Representativeness of the exposed cohort | Low risk | All adult CD patients who underwent ileocecal resection from 2010 to 2014 |
Selection of the non exposed cohort | Low risk | Both groups obtained from the same hospitals and time period |
Ascertainment of exposure | Low risk | Data collected prospectively in a standardized format by gastroenterologist |
Demonstration that outcome of interest was not present at start of study | High risk | 42% surgeries performed due to fistula/abscess |
Comparability of cohorts (Controlled for critical factor/other medications) | High risk | Did not control for other medications |
Comparability of cohorts (Controlled for additional factor) | High risk | Did not control of other factors |
Assessment of outcome | Low risk | Data collected prospectively in a standardized format and reviewed in detail |
Was follow‐up long enough for outcomes to occur | Low risk | 30 days |
Adequacy of follow up of cohorts | Unclear risk | No information provided |