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. 2020 Oct 24;2020(10):CD013256. doi: 10.1002/14651858.CD013256.pub2

Serradori 2013.

Study characteristics
Methods Retrospective, multicenter (3 institutions) cohort. Study period: 2000 to 2010
Participants Country: France. CD patients who underwent ileocecal or ileocolonic resection. Patients with temporary stomas were excluded.
Interventions 1. Preoperative anti‐TNF within 8 weeks of surgery
2. Preoperative steroids
Outcomes Intraabdominal abscess, anastomotic leak, fistula within 30 days of surgery
Notes NOS low risk of bias overall
Adjusted ORs for preoperative anti‐TNF and corticosteroids were obtained from multivariate regression analysis.
Risk of bias
Bias Authors' judgement Support for judgement
Representativeness of the exposed cohort Low risk CD patients who underwent ileocecal or ileocolonic resection from 2000 to 2010
Selection of the non exposed cohort Low risk Both groups obtained from the same database and time period
Ascertainment of exposure Low risk Medical charts reviewed
Demonstration that outcome of interest was not present at start of study High risk 30 patients had an abscess at the time of surgery
Comparability of cohorts (Controlled for critical factor/other medications) Low risk Controlled for steroids and anti‐TNF use
Comparability of cohorts (Controlled for additional factor) Low risk Also controlled for age, Montreal classification
Assessment of outcome Low risk Medical charts reviewed
Was follow‐up long enough for outcomes to occur Low risk 30 days
Adequacy of follow up of cohorts Unclear risk Information not provided