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. 2020 Oct 24;2020(10):CD013256. doi: 10.1002/14651858.CD013256.pub2
Study Reason for exclusion
Abelson 2018 Compared rates of surgical complications in IBD patients who underwent surgery between 1995 and 2005 vs 2005 and 2013. Did not compare preoperative medications.
Abou‐Khalil 2016 Studied patients with CD who were treated with immunosuppressants compared with those who were not. Authors clarified that the immunosuppressant group included patients treated with any of the following: mycophenolate mofetil, adalimumab, etanercept, azathioprine, cyclosporine, tacrolimus, sirolimus, infliximab, natalizumab, methotrexate and certolizumab pegol.
Achkasov 2015 Reported combined outcome of surgical site infection and parastomal complications. Unable to contact authors to obtain rate of only the infectious complications.
Adegbola 2018 Reported rates of intra‐abdominal septic complications in IBD patients who underwent ileocolonic resection. Did not report pre‐operative medications in patients who developed septic complications and those who did not develop septic complications. Unable to contact author for more information.
Aelvoet 2016 Compared patients treated with vedolizumab to those treated with infliximab.
Andrew 2017 Infectious outcomes were collected within the first 60 postoperative days.
Bafford 2013 Reported overall postoperative complications and not specifically infectious complications. Unable to contact authors for additional information.
Balachandran 2015 Recorded complications occurring within 3 months of surgery.
Benichou 2018 Did not specify number of patients with postoperative infections who were treated with and without anti‐TNF agents.
Bewtra 2013 Recorded complications occurring within 90 days of surgery.
Braun 2018 Did not report postoperative infectious complications.
Bruewer 2003 Did not specify time frame for postoperative complications. Unable to contact authors for confirmation.
Chaparro 2018 Described characteristics and indications for surgical interventions. Did not report postoperative complications.
Chiplunker 2015 No comparison group
Coscia 2012 Reported overall postoperative complications. Unable to contact authors to obtain rate of infectious complications.
Desai 2012 Postoperative infection was a secondary outcome but results were not reported in the abstract. Unable to obtain information from authors.
De Silva 2011 Complications were recorded from time of surgery to time of discharge from hospital. Range or mean length of stay in hospital was not reported. While infectious complications were reported, patients' medications were not specified. Unable to contact authors.
Domenech 2016 No comparison group.
Eisner 2014 Did not specify time frame for postoperative complications. Unable to contact authors for confirmation.
Fronda 1999 Did not specifically report infectious complications.
Fu 2014 Study did not compare rates of postoperative infection in IBD patients treated with different medications
Gamaleldin 2018 Did not report postoperative infections
George 2017 Included patients who did not have a diagnosis of IBD
Gonzalez 2013 Did not report postoperative infections
Grant 2019 Reported rates of wound healing following proctectomy but not postoperative infectious complications.
Gregory 2019 Reported 90 day postoperative infectious complications.
Heimann 1985 Reported postoperative infections but did not report how many of these patients were treated with steroids and how many were not treated with steroids. Unable to contact authors for confirmation.
Hyde 2001 Did not specify time frame for postoperative complications. Unable to contact authors for confirmation.
Justiniano 2019 Only reported postoperative mortality.
Kamel 2019 Reported effect of biologic agents on operative outcomes (length of small bowel resection, intraoperative blood loss and total operative time) but not postoperative infectious complications.
Kasparek 2012 Did not specify time frame for postoperative complications. Unable to contact authors for confirmation.
Kimura 2019 Did not provide rates of postoperative infectious complications for each category of preoperative medication.
Kline 2020 Did not examine relationship between preoperative medications and postoperative infectious complications.
Kotze 2011 Patient population included in Kotze 2017.
Kotze 2017a Patient population included in Kotze 2017.
Kotze 2018 Comparison group included patients without IBD
Krupa 2012 Did not specify time frame for postoperative complications. Unable to contact authors for confirmation.
Kulaylat 2017 Recorded complications occurring within 90 days of surgery.
Labidi 2018 There was no comparison group.
Lau 2013 Reported rates of postoperative infection in a graph, which was illegible. Unable to contact authors for additional information.
Li 2016 Reported overall postoperative complications but not specifically infectious complications.
Lightner 2017 Significant overlap with patients in Lightner 2018.
Lightner 2017a Compared vedolizumab treated patients to anti‐TNF treated patients.
Lightner 2018a Compared patients treated with ustekinumab to patients treated with anti‐TNF medications.
Lightner 2018b Compared patients treated with vedolizumab to patients treated with anti‐TNF medications.
Lim 2018 Reported surgical trends over time. Did not examine relationship between preoperative medications and postoperative infectious complications.
Melo‐Pinto 2018 Reported overall postoperative complications but not specifically infectious complications.
Monsinjon 2017 Reported overall postoperative complications but not specifically infectious complications.
Nagao 2016 Did not specify time frame for postoperative complications. Unable to contact authors for confirmation.
Novello 2019 Compared patients treated with ustekinumab to patients treated with vedolizumab.
Oh 2014 Mentioned that the rate of infectious complications was similar between treatment and comparison groups but did not actually report the rate. Unable to contact authors for additional information.
Park 2018 Compared patients treated with ustekinumab to patients treated with vedolizumab.
Parrish 2019 Did not compare different preoperative medications. Compared patients treated with ustekinumab with detectable levels before surgery to patients treated with ustekinumab with undetectable levels.
Poylin 2018 Compared patients treated with vedolizumab to those treated with an anti‐TNF agent.
Quade 2013 Reported overall postoperative complications but not specifically infectious complications.
Rizvi 2019 Reported postoperative infectious complications up to 6 months after surgery.
Sahami 2016 Did not specify time frame for postoperative complications. Unable to contact authors for confirmation.
Scarpa 2015 Reported overall postoperative complications but not specifically infectious complications.
Shim 2018 Compared patients treated with ustekinumab to patients treated with anti‐TNF medications.
Shimada 2016 Did not specify time frame for postoperative complications or rate of complications in the comparison group. Unable to contact authors for confirmation.
Stewart 2009 Reported infectious complications in a group of patients on some form of immunosuppression such as infliximab, cyclosporine, prednisone, or azathioprine. Contacted authors for separate rates of infectious complications in patients treated with each of these medications. However, the authors were unable to obtain this data.
Strassle 2017 Included patients with ulcerative colitis, Crohn's disease, or familial adenomatous polyposis.
Stringfield 2016 Lacked a comparison group.
Valizadeh 2017 Reported infectious complications in patients treated with either immunosuppressant medications or steroids. Did not analyse each type of medications separately.
Watson 2018 Reports rates of any postoperative complication but not specifically infectious complications.
Weber 2017 Did not report postoperative infectious complications.
Yamamoto 2016a Stated that neither immunosuppressive nor biologic therapy prior to surgery was significantly associated with the incidence of septic complications. Also stated that high dose steroid therapy significantly increased the risk of septic complications. Did not report any rates, odd ratio or risk ratio. Unable to contact author for additional information.
Yamamoto 2018 Included patients treated with either anti‐TNF medication or tacrolimus into one group in their analysis.