Date	Event	Description
1 July 2010	New search has been performed	Complete update with additional studies, revised analysis, risk of bias assessment, and revised conclusions. Specifically, the search has been updated from the end of 2007 to June 2010, with 5 new eligible studies identified; analyses are now based on the nature of the control arm. Targeted agents have now been validated as first and second‐line therapy choices for patients with advanced renal cancers of the clear cell subtype.
8 April 2010	New search has been performed	Converted to new review format.
14 January 2008	New citation required and conclusions have changed	Substantive amendment