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. 2010 Dec 3;21(1):1–15. doi: 10.1111/j.1750-3639.2010.00417.x

Figure 8.

Figure 8

Chronic treatment with a nitric oxide synthase (NOS) inhibitor partially prevents flat/pleomorphic (F/P)‐type bouton loss, but not spherical (S)‐type bouton gain, on hypoglossal motoneurons (HMNs) in hSOD1G93A mice. A. Segment of the plasma membrane of a HMN obtained from the indicated animal at 90 days postnatal that received Nω‐nitro‐L‐arginine methyl ester (L‐NAME) in the drinking water from 60 days postnatal. The solid arrows point to synaptic boutons attached to the plasma membrane. B. Average number of attached boutons per 100 µm of HMN perimeter at the indicated conditions. *P < 0.001, two‐way analysis of variance (ANOVA), post hoc Tukey's test, relative to non‐transgenic wild‐type (WT) mice. C. Average bouton frequency, characterized by the type of vesicles, attached to motoneurons obtained from the indicated conditions. n = 20 HMNs from three mice per condition. *,§P < 0.05, two‐way ANOVA, post hoc Tukey's test, relative to WT or to WT and hSOD1G93A mice, respectively. Error bars indicate standard error of the mean. Error bar, 1 µm.