Table 1.

General characteristics of included clinical practice guidelines (n=12)

Number	Author (year)	Full title	Countries covered	Origin	Primary audience	Design (systematic review, SR, used and methods thereafter)	Planned update given	Funding
1	Coleman et al (2012)30	Standards of care for the health of transsexual, transgender and gender non-conforming people V.7	Global	WPATH	Health professionals	Work groups submit manuscripts based on prior literature reviews, no explicit links of recommendations to evidence, expert consensus. No independent external review	No	Tawani Foundation and gift from anonymous donor
2	Davies et al (2015)51	Voice and communication change for gender non-conforming individuals: giving voice to the person inside	Global	WPATH	Speech-language therapists	Review of evidence. Expert consensus. No independent external review	No	Transgender Health Information Program of British Columbia Canada
3	ECDC (2018)58	Public health guidance on HIV, hepatitis B and C testing in the EU/EEA	EU/EEA	ECDC consortium CHIP, PHE, SSAT and EATG	Member states’ public health professionals who coordinate the development of national guidelines or programmes for HBV, HCV and HIV testing	Four SRs, SIGN, NICE and AXIS checklists. Ad hoc internal and external expert panel, independent chair, expert consensus. No independent external review	No	Commissioned by ECDC, contractor Rigshospitalet CHIP
4	Gilligan et al (2017)52	Patient-clinician communication: American Society of Clinical Oncology consensus guideline	USA and others	ASCO	Clinicians who care for adults with cancer	Nine questions (one SR), expert consensus and a Delphi exercise. No independent external review	Regular review 3-year check	None declared
5	Hembree et al (2017)53	Endocrine treatment of gender-dysphoric/gender-incongruent persons: an Endocrine Society clinical practice guideline	Global	Endocrine Society	Endocrinologists, trained mental health professionals and trained physicians	Two SRs and GRADE, rest expert consensus. No independent external review	No	Endocrine Society
6	IAPHCCO (2015)54	IAPAC guidelines for optimising the HIV care continuum for adults and adolescents	Global	IAPAC	Care providers, programme managers, policymakers, affected communities, organisations, and health systems involved with implementing HIV programmes and/or delivering HIV care	A systematic search of CDC database, expert consensus. No independent external review	No	IAPAC, US NIH and Office of AIDS Research
7	Ralph et al (2010)56	Trauma, gender reassignment and penile augmentation	Not specified (international publication)	Author group	Not stated (urological surgeons)	No SR. Unclear if literature review. Leading experts’ consensus opinion. No independent external review	No	None declared
8	Strang et al (2018)57	Initial clinical guidelines for co-occurring autism spectrum disorder and gender dysphoria or incongruence in adolescents	Not specified (international publication)	Author group	Clinicians	No SR or literature review. Two-stage Delphi consensus. No independent external review	No	Isadore and Bertha Gudelsky Family Foundation
9	T'Sjoen et al (2020)55	ESSM Position Statement ‘Assessment and hormonal management in adolescent and adult trans people, with attention for sexual function and satisfaction’	Europe	ESSM	European clinicians working in transgender health, sexologists and other healthcare professionals	No SR. Leading experts’ consensus opinion. No independent external review	No	ESSM
10	WHO (2011)48	Prevention and treatment of HIV and other sexually transmitted infections among men who have sex with men and transgender people. Recommendations for a public health approach	Global	WHO	National public health officials and managers of HIV/AIDS and STI programmes, NGOs including community and civil society organisations, and health workers	13 SRs for PICOs and GRADE, external GDG, and independent external review	Yes in 2015	BMZ and PEPFAR through CDC and USAID
11	WHO (2012)49	Guidance on oral pre-exposure prophylaxis for serodiscordant couples, men and transgender women who have sex with men at high risk of HIV. Recommendations for use in the context of demonstration projects	Global	WHO	Countries/member states	Four SRs (including values and preferences reviews) and GRADE, external GDG and independent external review group	Yes in 2015	Bill & Melinda Gates Foundation
12	WHO (2016)50	Consolidated guidelines on HIV prevention, diagnosis, treatment and care for key populations. 2016 update	Global	WHO	National HIV programme managers and other decision-makers within ministries of health and those responsible for health policies, programmes and services in prisons	Two new SRs in revised guidance, GRADE, external GDGs and 79 independent external peer reviewers	Regular updates; no detail	UNAIDS, PEPFAR, Global Fund

AACE, American Association of Clinical Endocrinologists; ASA, American Society of Andrology; ASCO, American Society of Clinical Oncology; ASD, autism spectrum disorder; AXIS, Appraisal Tool for Cross-Sectional Studies; BMZ, German Federal Ministry for Economic Cooperation and Development; CDC, the Centers for Disease Control and Prevention; CHIP, CHIP/Region H, Rigshospitalet, University of Copenhagen; CPG, clinical practice guideline; EATG, European AIDS Treatment Group; EAU, European Association of Urology; ECDC, European Centre for Disease Prevention and Control; ESE, European Society of Endocrinology; ESPE, European Society for Pediatric Endocrinology; ESSM, European Society for Sexual Medicine; EU/EEA, European Union/European Economic Area; GDG, guideline development group; Global Fund, Global Fund to Fight AIDS, Tuberculosis and Malaria; GRADE, Grading of Recommendations, Assessment, Development and Evaluation; HBV, hepatitis B virus; HCV, hepatitis C virus; IAPAC, International Association of Providers of AIDS Care; IAPHCCO, International Advisory Panel on HIV Care Continuum Optimization; NGO, non-governmental organisations; NICE, National Institute of Health and Care Excellence; NIH, National Institutes of Health; PEPFAR, US President’s Emergency Plan for AIDS Relief; PES, Pediatric Endocrine Society; PHE, Public Health England; PICO, Participants/patients, Intervention, Comparators, Outcomes; SIGN, Scottish Intercollegiate Guidelines Network; SR, systematic review; SSAT, St Stephen’s AIDS Trust; STI, sexually transmitted infection; UNAIDS, The Unified Budget, Results and Accountability Framework of the Joint United Nations Programme on HIV/AIDS; USAID, US Agency for International Development; WPATH, World Professional Association for Transgender Health.