| 1.1 Frequency of leg cramps during treatment |
1 |
38 |
Mean Difference (IV, Fixed, 95% CI) |
1.80 [‐1.32, 4.92] |
| 1.2 Frequency of leg cramps after treatment |
1 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
| 1.2.1 Daily |
1 |
69 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.20 [0.45, 3.21] |
| 1.2.2 Every other day |
1 |
69 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.44 [0.12, 1.57] |
| 1.2.3 Twice a week |
1 |
69 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.29 [0.11, 0.80] |
| 1.2.4 Once a week |
1 |
69 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.54 [0.62, 3.87] |
| 1.3 Frequency of leg cramps after treatment: never |
1 |
69 |
Risk Ratio (M‐H, Fixed, 95% CI) |
5.66 [1.35, 23.68] |
| 1.4 Frequency: 50% reduction in number of leg cramps |
1 |
86 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.42 [1.09, 1.86] |
| 1.5 Intensity of pain during treatment: mean total score |
1 |
38 |
Mean Difference (IV, Fixed, 95% CI) |
1.80 [‐3.10, 6.70] |
| 1.6 Intensity of pain: 50% reduction in pain score |
1 |
86 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.43 [0.99, 2.06] |
| 1.7 Intensity of pain: visual analogue scale |
1 |
69 |
Mean Difference (IV, Fixed, 95% CI) |
‐17.50 [‐34.68, ‐0.32] |
| 1.8 Duration: persisting symptoms after night‐time cramps |
1 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
| 1.8.1 Always |
1 |
69 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.23 [0.05, 0.98] |
| 1.8.2 Sometimes |
1 |
69 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.59 [0.19, 1.83] |
| 1.9 Composite outcome: symptoms of leg cramps (intensity and frequency) |
1 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
| 1.9.1 Partial improvement: decrease in intensity and frequency |
1 |
42 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.07 [0.71, 1.61] |
| 1.9.2 Complete recovery: no leg cramps after treatment |
1 |
42 |
Risk Ratio (M‐H, Fixed, 95% CI) |
3.00 [0.68, 13.20] |
| 1.10 Side effects |
2 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
| 1.10.1 Nausea |
1 |
86 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.83 [0.75, 4.51] |
| 1.10.2 Diarrhoea |
1 |
86 |
Risk Ratio (M‐H, Fixed, 95% CI) |
6.00 [0.75, 47.76] |
| 1.10.3 Any side effect (including nausea, flatulence, diarrhoea and intestinal air) |
1 |
45 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.96 [0.36, 2.52] |
