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. 2021 Mar 18;2021(3):CD011424. doi: 10.1002/14651858.CD011424.pub3

Mahran 2015.

Study characteristics
Methods Randomised controlled trial, 2 groups, set in Minia Infertility Research Unit, Egypt
June 2012 to May 2014
Number of participants randomised: 200
Number of participants analysed: unknown
Participants Inclusion and exclusion criteria: not described
Cause of infertility: unexplained
Interventions
  • Intervention group: endometrial scratching performed once on Day 21 of the cycle preceding the intrauterine insemination (IUI) cycle

  • Control group: "no intervention"


Degree of endometrial injury: pipelle
Timing of endometrial injury: in the luteal phase (on Day 21) of the cycle preceding the IUI cycle
Study length: 1 cycle
Type of conception: IUI
Outcomes Reported in the paper:
  • Clinical pregnancy (not defined, only percentages were given; therefore data could not be used in the meta‐analysis)

Notes Only a conference abstract was available
Funding source: not described
Conflicts of interest: not described
Trial registration: not found
Author correspondence was undertaken, but we did not receive a response
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Randomisation method was not described
Allocation concealment (selection bias) Unclear risk Abstract did not report whether allocation concealment was performed
Blinding of participants (performance bias) High risk Abstract did not report blinding of participants, and it was unlikely; lack of participant blinding is anticipated to introduce performance bias
Blinding of personnel (performance bias) High risk Abstract did not report any blinding of personnel
Blinding of outcome assessment (detection bias)
All outcomes Low risk Abstract did not report blinding of outcome assessors, and it was unlikely; outcomes were unlikely to be influenced by lack of blinding, as there were no patient‐reported outcomes
Incomplete outcome data (attrition bias)
All outcomes Unclear risk Abstract did not report any information about missing data
Selective reporting (reporting bias) Unclear risk We did not find a trial registration number or protocol
Other bias Unclear risk Information is insufficient to show whether an important risk of bias exists