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. 2021 Mar 18;2021(3):CD011424. doi: 10.1002/14651858.CD011424.pub3

Parsanezhad 2012.

Methods Unclear whether this is a randomised controlled trial, as it is described as "randomised case‐control study"
Number of participants randomised: 139
Number of participants analysed: unknown
Participants Quote: "unexplained infertile patients undergoing intrauterine insemination (IUI)"
Interventions
  • Intervention group: endometrial injury performed in the posterior wall of the uterus by Novak curette (on the day of human chorionic gonadotropin (hCG) injection)

  • Control group: no endometrial injury


Both groups:
Quote: "after superovulation by clomiphene citrate and gonadotropins and when the dominant follicles reached 18‐20 mm, 10,000 UI hCG was injected. All patients underwent single IUI after 36 hours"
Degree of endometrial injury: Novak curette
Timing of endometrial injury: on the day of hCG injection
Type of conception: IUI
Outcomes Clinical and ongoing pregnancy rates
Notes Abstract for the 3rd International and 18th National Congress of Iranian Society for Reproductive Medicine (18 to 20 April 2012)
Author correspondence was undertaken, but we did not receive a response
This study is awaiting classification, as it shows many similarities with Zarei 2014, and it is unclear whether these studies are different. For example, both studies have the same setting (Shiraz University of Medical Sciences), comparable study groups (women with unexplained infertility undergoing stimulated IUI cycles), and a comparable number of included participants (Parsanezhad 2012, n = 139, and Zarei 2014, n = 146). It is likely that both studies were conducted in overlapping time periods. Studies differ in the timing of endometrial injury performed. In Zarei 2014, endometrial injury was performed on Day 6 to 8 of the menstrual cycle before IUI, whereas in Parsanezhad 2012, the procedure was performed on the same day as hCG injection in the IUI cycle

BMI: body mass index; FSH: follicle‐stimulating hormone; hCG: human chorionic gonadotropin; IUI: intrauterine insemination; IVF: in vitro fertilisation.