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. 2021 Feb 12;2021(2):CD013587. doi: 10.1002/14651858.CD013587.pub2

2. Ongoing trials for prevention: actively recruiting or completed; not yet published.

Trial registration number; trial registry Location(s) Interventions; population; abbreviated name Recruitment status Estimated completion Target enrolment
NCT04333732
ClinicalTrials.gov
USA Low‐/medium‐/high‐dose chloroquine vs placebo
Healthcare workers
Recruiting February 2021 55,000
NCT04303507
ClinicalTrials.gov 
Europe, Asia, Africa HQC vs CQ vs placebo
Healthcare workers
COPCOV
Recruiting April 2021 40,000
NCT04334928
ClinicalTrials.gov Spain Emtricitabine/tenofovir (Truvada) vs HCQ vs Truvada + HCQ vs placebo
Healthcare workers
EPICOS
Recruiting  June 2020 4000
NCT04334148
ClinicalTrials.gov
USA HCQ vs placebo
Healthcare workers
Recruiting July 2020 15,000
NCT04363450
ClinicalTrials.gov 
USA HCQ vs placebo
Healthcare workers (pre‐exposure)
HCQPreP
Recruiting July 2020 1700
NCT04318444
ClinicalTrials.gov
USA HCQ vs placebo
Household contacts (postexposure)
Recruiting March 2021 1600
NCT04341441
ClinicalTrials.gov
USA Daily HCQ vs weekly HCQ vs placebo
Healthcare workers and first responders
Recruiting June 2020 3000
IRCT20190122042450N4
Iranian Clinical Trials Registry Iran HCQ vs no HCQ
All contacts (postexposure)
Completed Not reported 1000
ISRCTN14326006
ISRCTN registry
Canada HCQ vs placebo
Healthcare workers
Recruiting January 2022 988
NCT04363827
ClinicalTrials.gov
Italy  HCQ vs no HCQ
All contacts
Recruiting September 2020 2300 
NCT04352933
ClinicalTrials.gov
UK HCQ weekly vs HCQ daily vs placebo
Healthcare workers
Recruiting October 2020 1000
NCT04353037
ClinicalTrials.gov
USA HCQ vs placebo
Healthcare workers 
Recruiting  April 2021 850 
ACTRN12620000501943
ANZCTR
Australia HCQ vs placebo
Healthcare workers 
Recruiting December 2020 2250
NCT04374942
ClinicalTrials.gov
USA HCQ vs placebo
Healthcare workers 
Recruiting  January 2022 988
EudraCT 2020‐001987‐28
EudraCT
Italy HCQ vs no HCQ
Healthcare workers
Recruiting Not reported 1000

CQ, chloroquine; HCQ, hydroxychloroquine