Comparison 2. NSAID versus opioid.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
2.1 Adequate pain relief as reported by the woman	5	560	Risk Ratio (M‐H, Fixed, 95% CI)	1.33 [1.13, 1.57]
2.1.1 Aspirin 650 mg versus codeine 60mg	1	33	Risk Ratio (M‐H, Fixed, 95% CI)	1.03 [0.65, 1.61]
2.1.2 Aspirin 650 mg versus codeine 120 mg	1	33	Risk Ratio (M‐H, Fixed, 95% CI)	1.13 [0.69, 1.84]
2.1.3 Fenoprofen 12.5 mg versus codeine 60 mg	1	32	Risk Ratio (M‐H, Fixed, 95% CI)	1.11 [0.35, 3.52]
2.1.4 Fenoprofen 25 mg versus codeine 60 mg	1	32	Risk Ratio (M‐H, Fixed, 95% CI)	0.93 [0.42, 2.04]
2.1.5 Fenoprofen 50 mg versus codeine 60 mg	2	66	Risk Ratio (M‐H, Fixed, 95% CI)	1.24 [0.68, 2.27]
2.1.6 Fenoprofen 100 mg versus codeine 60 mg	2	69	Risk Ratio (M‐H, Fixed, 95% CI)	1.44 [0.77, 2.66]
2.1.7 Fenoprofen 200 mg versus codeine 60 mg	3	92	Risk Ratio (M‐H, Fixed, 95% CI)	1.42 [0.81, 2.47]
2.1.8 Fenoprofen 300 mg versus codeine 60 mg	1	37	Risk Ratio (M‐H, Fixed, 95% CI)	1.84 [0.73, 4.65]
2.1.9 Flurbiprofen 50 mg versus codeine 60 mg	1	31	Risk Ratio (M‐H, Fixed, 95% CI)	1.26 [0.86, 1.85]
2.1.10 Flurbiprofen 50 mg versus codeine 120 mg	1	30	Risk Ratio (M‐H, Fixed, 95% CI)	1.30 [0.86, 1.96]
2.1.11 Naproxen 300 mg versus codeine 60 mg	1	52	Risk Ratio (M‐H, Fixed, 95% CI)	1.46 [0.90, 2.36]
2.1.12 Naproxen 600 mg versus codeine 60 mg	1	53	Risk Ratio (M‐H, Fixed, 95% CI)	1.71 [1.06, 2.77]
2.2 Need for additional pain relief	2	232	Risk Ratio (M‐H, Fixed, 95% CI)	0.37 [0.12, 1.12]
2.2.1 Aspirin 650 mg versus codeine 60 mg	1	33	Risk Ratio (M‐H, Fixed, 95% CI)	0.94 [0.06, 13.82]
2.2.2 Aspirin 650 mg versus codeine 120 mg	1	32	Risk Ratio (M‐H, Fixed, 95% CI)	2.67 [0.12, 60.93]
2.2.3 Flurbiprofen 50 mg versus codeine 60 mg	1	31	Risk Ratio (M‐H, Fixed, 95% CI)	Not estimable
2.2.4 Flurbiprofen 50 mg versus codeine 120 mg	1	31	Risk Ratio (M‐H, Fixed, 95% CI)	0.35 [0.02, 8.08]
2.2.5 Naproxen 300 mg versus codeine 60 mg	1	52	Risk Ratio (M‐H, Fixed, 95% CI)	0.10 [0.01, 1.98]
2.2.6 Naproxen 600 mg versus codeine 60 mg	1	53	Risk Ratio (M‐H, Fixed, 95% CI)	0.11 [0.01, 2.09]
2.3 Maternal adverse events	3	255	Risk Ratio (M‐H, Fixed, 95% CI)	0.62 [0.43, 0.89]
2.3.1 Aspirin 650 mg versus codeine 60 mg	1	33	Risk Ratio (M‐H, Fixed, 95% CI)	0.75 [0.24, 2.32]
2.3.2 Aspirin 650 mg versus codeine 120mg	1	33	Risk Ratio (M‐H, Fixed, 95% CI)	0.27 [0.11, 0.65]
2.3.3 Fenoprofen 200 mg versus codeine 60 mg	1	23	Risk Ratio (M‐H, Fixed, 95% CI)	1.83 [0.60, 5.61]
2.3.4 Flurbiprofen 50 mg versus codeine 60 mg	1	31	Risk Ratio (M‐H, Fixed, 95% CI)	0.64 [0.18, 2.22]
2.3.5 Flurbiprofen 50 mg versus codeine 120 mg	1	30	Risk Ratio (M‐H, Fixed, 95% CI)	0.23 [0.08, 0.65]
2.3.6 Naproxen 300 mg versus codeine 60 mg	1	52	Risk Ratio (M‐H, Fixed, 95% CI)	1.09 [0.39, 3.05]
2.3.7 Naproxen 600 mg versus codeine 60 mg	1	53	Risk Ratio (M‐H, Fixed, 95% CI)	1.16 [0.41, 3.25]