Summary of findings 6. Myofunctional therapy plus nasal washing compared to Nasal washing alone for obstructive sleep apnoea.
| Myofunctional therapy plus nasal washing compared to nasal washing alone for obstructive sleep apnoea | ||||||
| Patient or population: Obstructive sleep apnoea Setting: Outpatient Intervention: Myofunctional therapy plus nasal washing Comparison: Nasal washing alone | ||||||
| Outcomes | Anticipated absolute effects* (95% CI) | Relative effect (95% CI) | № of participants (studies) | Certainty of the evidence (GRADE) | Comments | |
| Risk with Nasal washing alone | Risk with Myofunctional therapy plus nasal washing | |||||
| AHI score reduction to below 5 points. Follow‐up: 2 months. | Study population | OR 12.50 (0.84 to 186.30) |
13 (1 RCT) | ⊕⊕⊝⊝ LOW1 2 | May result in little to no difference in AHI. Events per hour. Lower scores better. MCID 5 points. |
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| 167 per 1000 | 714 per 1000 (144 to 974) | |||||
| AHI score change. Follow‐up: 2 months. | The mean AHI score change was 1.32 | MD 3 higher (0.26 lower to 6.26 higher) | ‐ | 13 (1 RCT) | ⊕⊕⊝⊝ LOW1 2 | May result in little to no difference in AHI. Events per hour. Lower scores better. MCID 5 points. Endpoint analysis: MD 3.54 lower (7.72 lower to 0.64 higher). |
| *The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). AHI: apnoea hypopnoea index; CI: Confidence interval; ESS: Epworth sleepiness scale; MD: mean difference; MCID: Minimal Clinically Important Diference; OR: odds ratio; PSQI: Pittsburgh Sleep Quality Index | ||||||
| GRADE Working Group grades of evidence High certainty: We are very confident that the true effect lies close to that of the estimate of the effect Moderate certainty: We are moderately confident in the effect estimate: The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different Low certainty: Our confidence in the effect estimate is limited: The true effect may be substantially different from the estimate of the effect Very low certainty: We have very little confidence in the effect estimate: The true effect is likely to be substantially different from the estimate of effect | ||||||
1 Downgraded one point for unblinded
2 Downgraded one point for imprecision