| Study | Reason for exclusion |
|---|---|
| Ansaldi 1988 | Cross‐over study with PERT for 5 days in each arm. |
| Araujo 2011 | Doesn't appear to have a control group, PERT dosage increased according to fecal fat levels. |
| Beker 1994 | Cross‐over study with PERT for 3 days in each arm. |
| Beverley 1987 | Cross‐over study with 3 arms of 15 days each. |
| Borowitz 2011 | The study drugs were given for a period of 6 days only after randomisation. |
| Bouquet 1988 | Cross‐over study with each treatment period only 2 weeks. |
| Bowler 1993 | Crossover study with 2 arms of 2 weeks each. |
| Brady 1991 | Crossover study with 2 arms of 7 days each. |
| Brady 1992 | Cross‐over study of enzymes given before and during meals; 2 periods of 1 week each. |
| Brady 2006 | Cross‐over study with 2 treatment periods of 1 week each. |
| Breuel 1996 | Study assesses pancreatic enzyme activity. |
| Butt 2001 | Study assesses breath tests. |
| Chazalette 1988 | Open label cross‐over study with periods of 1 week each. |
| Chazalette 1993 | Parallel group study for a period of 8 days. |
| Colombo 2001 | Study compares different methods for assessing exocrine pancreatic function. |
| Dalzell 1992 | Meets inclusion criteria, but data not in usable format and will not be made available in the future |
| De Boeck 1998 | Single dose intervention. |
| Desager 2006 | Parallel study period of 10 days. |
| Duhamel 1988 | Cross‐over study with 2 periods of 8 days each. |
| Duhamel 1998 | Cross‐over study with 2 periods of 14 days each. Study assessed patient preference, but also assessed clinical symptoms. |
| Durie 1980 | Cross‐over study with 4 preparations given for 1 week each. |
| Dutta 1988 | Crossover study with each intervention given only on a single day. |
| Easley 1998 | Cross‐over study with each intervention given only on a single day. |
| Eiel 2018 | Intervention not relevant |
| Ellis 1994 | Cross‐over study (assessing coating of PERT) with 2 weeks in each arm. |
| EUCTR 2007‐004004‐12 | Participants not relevant (chronic pancreatitis & pancreatectomy) |
| EUCTR 2015‐001219‐11 | Treatment period of 7 days |
| Foucaud 1989 | Placebo‐controlled, parallel study but treatment period for 1 week. |
| Gan 1994 | Cross‐over study with 2 arms of 14 days each. |
| Geyer 2019 | Intervention not relevant |
| Goodchild 1974 | Cross‐over study with 2 weeks in each arm. |
| Gow 1981 | Cross‐over study of 4 periods of 14 days each. |
| Graff 2010 | Intervention given for 5 days. |
| Heubi 2007 | Cross‐over placebo‐controlled trial with 2 periods of 1 week each. |
| Heubi 2016 | Cross‐over study with 1 week in each arm. |
| Hill 1993 | Letter reports cross‐over trial to compare patient preference of different formulations; no other outcomes stated. |
| Hilman 1982 | Cross‐over study with a total 2‐week study period. |
| Holsclaw 1979 | Cross‐over study of 6 treatment (Viokase vs Cotazyme vs Pancrelipase with and without bicarbonate) periods of 3 weeks each. |
| Hubbard 1984 | Study assesses use of bentiromide screening test. |
| Kalnins 2005 | Cross‐over study with 2 treatment periods of 2 weeks each. |
| Kalnins 2006 | Cross‐over study with 2 treatment periods of 14 days each. |
| Katona 2000 | Not an RCT or a quasi‐RCT. |
| Khaw 1977 | Cross‐over study with two treatment periods of 12 days each. |
| Konstan 2004 | Intervention given only for 6 days. |
| Konstan 2008 | Cross‐over trial with 2 treatment periods of 5 days each. |
| Konstan 2010 | Treatment only 6 to 7 days in each arm of the 2‐phase cross‐over trial. |
| Kraisinger 1993 | Cross‐over trial with 2 treatment periods of 4 days each. |
| Lancellotti 1996 | Open‐label, cross‐over study with 2 treatment periods of 5 days each. |
| Lazaro 1990 | Cross‐over trial with 2 periods of 6 days each. |
| Leitz 2009 | Placebo‐controlled trial with a treatment period of 1 day. |
| Lubin 1979 | Study assesses use of antacids in conjunction with PERT intervention not relevant. |
| Mack 1991 | Cross‐over study assessing antibiotic absorption with PERT compared to without in a single intervention. |
| Mischler 1980 | Cross‐over study with 2 arms of 5 days each. |
| Mischler 1982 | Cross‐over trial 2 periods of 5 days each. |
| Morrison 1992 | Not an RCT or quasi‐RCT. |
| Munck 2009 | Cross‐over study with 2 treatment periods of 2 weeks each. |
| Munoz 1987 | Cross‐over study with 2 treatment periods of 1 week each. |
| NCT00217204 | Treatment period of 5 days. |
| NCT00449904 | Not an RCT |
| NCT01327703 | Cross‐over trial with treatment period of 14 days in each arm |
| NCT01652157 | Not an RCT |
| NCT01851694 | Intervention and outcomes not relevant. |
| NCT01858519 | Not an RCT |
| NCT02137382 | Cross‐over study with Creon/Creon N for 5 days in each arm. |
| NCT03746483 | Cross‐over study with 3 weeks in each arm |
| Neijens 1982 | Cross‐over study with treatment periods of 2 weeks each. |
| Perano 2014 | Cross‐over trial with 2 single interventions on separate days. |
| Ritz 2004 | Study evaluated a breath test used to assess fat malabsorption and not PERT. |
| Robinson 1989 | Cross‐over study with 2 treatment periods of 2 weeks each. |
| Robinson 1998 | Cross‐over study with 2 periods of 2 weeks each. |
| Santini 2000 | Cross‐over study with 2 treatment periods of 1 week each. |
| Shah 1993 | PERT taken for 2‐week period only. |
| Sinaasappel 1998 | Cross‐over trial with 2 periods of 14 days each. |
| Stapleton 2001 | Study assessing knowledge and education of PERT. |
| Stern 2000 | Parallel RCT but duration only 5 ‐ 7 days. |
| Thomson 1993 | Cross‐over trial with 3 periods of 7 days each. |
| Trapnell 2009 | Cross‐over RCT with 5‐day course of PERT and same for placebo. |
| van der Haak 2016 | Intervention not relevant. |
| Van de Vijver 2011 | Treatment period only 5 days. |
| Vitti 1975 | Study assesses antibiotic absorption when given with PERT. |
| Warwick 1982 | Cross‐over study with 2 treatment periods of 1 week each. |
| Weber 1979 | Cross‐over study with 2 periods of 8 days each. |
| Wooldridge 2009 | Cross‐over study with 2 periods of 7 days each, followed by a non‐randomised extension study. |
| Zentler 1992 | RCT with 3 interventions for 2 weeks each. |
PERT: pancreatic enzyme replacement therapy RCT: randomized controlled trial vs: versus