Source	Search strategy	Hits retrieved
1. ALOIS (www.medicine.ox.ac.uk/alois) [date of latest search: 24 June 2020]	Souvenaid OR Fortasyn	Feb 2016: 7 Jan 2017: 0 Mar 2018: 0 May 2019: 0 June 2020: 2
2. MEDLINE In‐process and other non‐indexed citations and MEDLINE 1950‐present (Ovid SP) [date of latest search: 24 June 2020]	1. dement*.ti,ab. 2. exp *Dementia/ 3. alzheimer*.ti,ab. 4. (AD or "ADD").ti. 5. 1 or 2 or 3 or 4 6. souvenaid.ti,ab. 7. "Fortasyn Connect*".ti,ab. 8. ("medical food" and memory).ti,ab. 9. 6 or 7 or 8 10. 5 and 9	Feb 2016: 24 Jan 2017: 2 Mar 2018: 5 May 2019: 2 June 2020: 4
3. EMBASE 1974 ‐ present [date of latest search: 24 June 2020]	1. dement*.ti,ab. 2. exp *Dementia/ 3. alzheimer*.ti,ab. 4. (AD or "ADD").ti. 5. 1 or 2 or 3 or 4 6. souvenaid.ti,ab. 7. "Fortasyn Connect*".ti,ab. 8. ("medical food" and memory).ti,ab. 9. 6 or 7 or 8 10. 5 and 9	Feb 2016: 104 Jan 2016: 9 Mar 2018: 25 May 2019: 9 June 2020: 14
4. PSYCINFO 1967 ‐ present [date of latest search: 24 June 2020]	1. dement*.ti,ab. 2. exp *Dementia/ 3. alzheimer*.ti,ab. 4. (AD or "ADD").ti. 5. 1 or 2 or 3 or 4 6. souvenaid.ti,ab. 7. "Fortasyn Connect*".ti,ab. 8. ("medical food" and memory).ti,ab. 9. 6 or 7 or 8 10. 5 and 9	Feb 2016: 10 Jan 2017: 1 Mar 2018: 3 May 2019: 5 June 2020: 1
5. CINAHL (EBSCOhost) [date of latest search: 24 June 2020]	S1. TX dement* OR SU Dementia OR TX alzheimer* OR TI (AD or "ADD") S2. TX souvenaid OR TX "Fortasyn Connect*" OR TX ("medical food" and memory) S3. (S1 AND S2)	Feb 2016: 2 Jan 2017: 0 Mar 2018: 0 May 2019: 3 June 2020: 2
6. ISI Web of Science – all databases [includes: Web of Science (1945‐present); BIOSIS Previews (1926‐present); MEDLINE (1950‐present); Journal Citation Reports] [date of latest search: 24 June 2020]	(dement* OR alzheimer* OR AD OR ADD) AND TOPIC: (souvenaid OR "Fortasyn Connect*" OR ("medical food" and memory)) Timespan=All years Search language=Auto	Feb 2016: 50 Jan 2017: 6 Mar 2018: 12 May 2019: 6 June 2020: 8
7. LILACS (BIREME) [date of latest search: 24 June 2020]	dement* OR alzheimer* OR AD OR ADD [Words] and souvenaid OR "Fortasyn Connect*" OR "medical food" [Words]	Feb 2016: 0 Jan2017: 0 Mar 2018: 0 May 2019: 0 June 2020: 0
8. CENTRAL (The Cochrane Library) http://crso.cochrane.org/SearchSimple.php [date of latest search: 24 June 2020]	#1 Dementia:MH #2 dement*:TI,AB,KY #3 alzheimer:MH #4 alzheimer*:TI,AB,KY #5 (AD or "ADD"):TI,AB,KY #6 #1 OR #2 OR #3 OR #4 OR #5 #7 souvenaid:TI,AB,KY #8 ("Fortasyn Connect*"):TI,AB,KY #9 ("medical food" and memory):TI,AB,KY #10 #7 OR #8 OR #9 #11 #6 AND #10	Feb 2016: 25 Jan 2016: 5 Mar 2018: 9 May 2019: 15 June 2020: 14
9. Clinicaltrials.gov (www.clinicaltrials.gov) [date of latest search: 24 June 2020]	Advanved search: [Condition: dementia OR "mild cognitive impairment" OR MCI OR alzheimers OR Alzheimer] AND [Intervention: souvenaid OR fortasyn] No date restrictions No trial status restrictions	Feb 2016: 0 Jan 2017: 0 Mar 2018: 0 May 2019: 0 June 2020:
10. ICTRP Search Portal (http://apps.who.int/trialsearch) [includes: Australian New Zealand Clinical Trials Registry; ClinicalTrilas.gov; ISRCTN; Chinese Clinical Trial Registry; Clinical Trials Registry – India; Clinical Research Information Service – Republic of Korea; German Clinical Trials Register; Iranian Registry of Clinical Trials; Japan Primary Registries Network; Pan African Clinical Trial Registry; Sri Lanka Clinical Trials Registry; The Netherlands National Trial Register] [date of latest search: 10 May 2019. n.b. database unavailable 24 June 2020]	dement* OR alzheimer* OR AD OR ADD in the Condition And souvenaid OR Fortasyn in the Intervention	Feb 2016: 7 Jan 2017: 0 Mar 2018: 1 May 2019: 0
TOTAL before de‐duplication		Feb 2016: 229 Jan 2017: 23 Mar 2018: 55 May 2019: 39 June 2020: 45 TOTAL: 391
TOTAL after de‐duplication		Feb 2016: 187 Jan 2017: 12 Mar 2018: 23 May 2019: 31 June 2020: 30 TOTAL: 283