ChiCTR‐IOR‐16008961.

Study name	An assessor‐blind, open‐label, randomised, parallel‐group, non‐inferiority study to compare the clinical pregnancy rate of interventional ultrasound sclerotherapy to surgical intervention on women with hydrosalpinx before in vitro fertilization and embryo transfer
Methods	Parallel RCT
Participants	Inclusion criteria: 1. Patients with unilateral or bilateral hydrosalpinges visible by ultrasound; 2. Aged between 20 to 37 years; 3. Period of infertility > 1 year; 4. Body mass index between 19 and 29; 5. Normal basal luteinizing hormone (LH), follicle stimulating hormone (FSH) and prolactin concentrations; 6. AFC = 7; 7. AMH level 0.24 to 11.78ng/ml; 8. Midluteal phase gonadotropin‐releasing hormone agonist (GnRH‐a) long down‐regulation protocol; 9. Normal recent semen analysis (according to WHO criteria). Exclusion criteria: 1. Uterine fibroid requiring surgical removal; 2. Endometriosis or adenomyosis; 3. Male factor of infertility requiring ICSI; 4. Previous IVF cycles; 5. History of recurrent miscarriage; 6. Endocrinologic disorders; 7. Presence of systemic disease contraindicating pregnancy.
Interventions	Control group: surgery group (not specified). Experimental group: ultrasound sclerotherapy.
Outcomes	1. Clinical pregnancy rate (not defined) 2. Live birth rate (not defined) 3. Pregnancy loss rate (not defined) 4. Ectopic pregnancy rate (not defined) 5. Ongoing pregnancy in a transfer cycle (not defined).
Starting date	Recruitment pending
Contact information	duxin@jarodx.com
Notes	Written correspondence to the authors remained unanswered up to the date of publication of this review.