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. 2020 Oct 22;2020(10):CD002125. doi: 10.1002/14651858.CD002125.pub4

ISRCTN40458453.

Study name The comparison of pregnancy outcomes in hydrosalpinx patients treated with salpingectomy and proximal tubal occlusion prior to in vitro fertilization embryo transfer: a randomised controlled study
Methods Single‐centre prospective randomised controlled study.
Participants 100 women with tubal disease prior to IVF.
Inclusion criteria: Women with tubal infertility planning to undergo IVF; 18‐41 years old.
Exclusion criteria: Endometriosis; prior ovarian surgery; diminished ovarian reserve; polycystic ovarian syndrome (PCOS).
Interventions Group 1: Modified laparoscopic “core‐pulling” salpingectomy. All salpingectomies performed laparoscopically.
Group 2: Modified laparoscopic proximal tubal occlusion. Proximal tubal occlusion also performed laparoscopically.
Outcomes 1. Clinical pregnancy, defined as gestation sac and/or fetal pole measured using ultrasound scan at 22 days after embryo transfer
2. Ongoing pregnancy, defined as a fetal heartbeat measured on ultrasound beyond 10 weeks of gestation
3. Implantation rate, defined as the number of gestational sacs on ultrasound divided by the number of embryos transferred, measured using ultrasound scan at 22 days after embryo transfer
4. Ectopic pregnancy at any extrauterine site (considered as an implanted embryo), measured using ultrasound scan at 22 days and 35 days after embryo transfer
5. Miscarriage, measured during the first trimester
6. Live birth rate, measured at birth
7. Ovarian reserve, measured using FSH levels on cycle day 2‐3 before and 3 months after the laparoscopic surgery
Starting date 1 January 2017
Contact information zhangsongying@zju.edu.cn
Notes Although the study's recruitment status is advertised as "completed" in the WHO International Clinical Trials Registry Platform, written correspondence to the authors remained unanswered up to the date of publication of this review.