Summary of findings 2. Embryo culture supernatant compared to culture medium injection for subfertile women in assisted reproduction.
| Embryo culture supernatant compared to culture medium injection for subfertile women in assisted reproduction | ||||||
| Patient or population: Subfertile women undergoing assisted reproduction Setting: IVF Units Intervention: Embryo culture supernatant injection before embryo transfer Comparison: Culture medium injection | ||||||
| Outcomes | Anticipated absolute effects* (95% CI) | Relative effect (95% CI) | № of participants (studies) | Quality of the evidence (GRADE) | Comments | |
| Risk with culture medium injection | Risk with embryo culture supernatant | |||||
| Live birth/ongoing pregnancy | Not reported in any study in this comparison | |||||
| Miscarriage | Not reported in any study in this comparison | |||||
| Clinical pregnancy | 583 per 1,000 | 604 per 1,000 (402 to 775) | OR 1.09 (0.48 to 2.46) | 96 (1 RCT) | ⊕⊝⊝⊝ VERY LOW1,2 | |
| Ectopic pregnancy | Not reported in any study in this comparison | |||||
| Multiple pregnancy | Not reported in any study in this comparison | |||||
| Preterm delivery | Not reported in any study in this comparison | |||||
| Foetal abnormalities | Not reported in any study in this comparison | |||||
| *The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: Confidence interval; RR: Risk ratio; OR: Odds ratio; | ||||||
| GRADE Working Group grades of evidence High quality: further research is very unlikely to change our confidence in the estimate of effect. Moderate quality: further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. Low quality: further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. Very low quality: we are very uncertain about the estimate. | ||||||
1Downgraded two levels for imprecision; wide CIs and low number of events 2 Downgraded one level due to studies at high risk of bias and unclear risk of publication bias