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. 2021 May 4;22:135. doi: 10.1186/s12931-021-01714-y

Table 2.

Unadjusted incidence rates and cumulative incidence of events in patients newly treated with antifibrotic drugs

Unadjusted incidence rate
[95% CI] (per 100 person-years)
One-year cumulative incidence of event, % [95% CI] Three-year cumulative incidence of event, % [95% CI]
All-cause mortality
Patients initiating pirfenidone 10.91 [8.81–13.51] 9.79 [7.41–12.56] 25.46 [19.60–31.71]
Patients initiating nintedanib 15.36 [12.13–19.44] 14.25 [10.81–18.14] 31.11 [21.16–41.56]
Acute respiratory-related hospital admissions
Patients initiating pirfenidone 26.99 [23.34–31.21] 22.85 [19.35–26.52] 48.26 [39.76–56.24]
Patients initiating nintedanib 30.70 [25.69–36.68] 27.46 [22.95–32.14] 43.62 [30.75–55.79]
Treatment discontinuation
Patients initiating pirfenidone 82.88 [75.27–91.26] 53.75 [50.13–57.22]
Patients initiating nintedanib 64.82 [56.85–73.91] 46.53 [41.96–50.97]

CI confidence interval