Fig. 1.

Experimental design. a Sample cohorts from MSBB, Mayo, and ROSMAP were combined across platforms by consensus SNP variant sites. Ancestry analysis was performed, and sites within the 2003 CEU ancestrally matched populations were filtered for consensus with the LD reference panel. b RNA-Seq samples originated from 6 distinct neocortical regions. c The training set data for training TWAS weights consisted of 888 RNA-Seq samples matched to 789 individual variant profiles