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. 2021 May 4;13:76. doi: 10.1186/s13073-021-00890-2

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Transcriptome-wide association study results. a Log 10 TWAS association p values by gene shown by genomic location are indicated in black and grey. Features passing initial correction for multiple comparisons (above the dotted line), but marginally significant after joint conditional probability (JCP) are shown in purple. Those features which are no longer significant after JCP are shown in light blue, while genes surviving JCP are shown in yellow. b QQplot of all TWAS p values. c An example plot of a region tested for JCP. The candidate genes found to be marginally significant, NUP160 and PTPRJ, are colored blue while those found to be jointly significant, MADD and MTCH2, are colored green (upper), while individual SNP p values are colored grey before and blue after conditioning (lower)