3. Most common dosages, routes, and time points of administration of single drugs of direct interest (primary outcome: vomiting).

Drug	Dose	Dose category	Route	Timing
Amisulpride	5 to 10 mg	rec	IV	at induction of AN
Aprepitant	40 mg	rec	PO	before surgery
Casopitant	150 mg	rec	PO	before surgery
Dexamethasone*	4 to 5 mg	rec	IV	at induction of AN
Dimenhydrinate	< 1 mg/kg	low	IV/IM	at induction of AN/before surgery
Dolasetron	12.5 mg	rec	IV	end of surgery
Droperidol	0.625 to 1.25 mg	rec	IV	at induction of AN
Fosaprepitant	150 mg	NA	IV	at induction of AN
Granisetron	0.35 to 3 mg	rec	IV	all time points
Haloperidol	0.5 to < 2 mg	rec	IV	at induction of AN
Metoclopramide	25 to 50 mg	low	IV	at induction of AN
Ondansetron (IV)	4 mg	rec	IV	at induction of AN
Ondansetron (PO)	8 mg	rec	PO	before surgery
Palonosetron	0.075 mg	rec	IV	at induction of AN
Promethazine**	< 6.25 mg	low	IV	at induction of AN
Ramosetron (IV)	0.3 mg	rec	IV	end of surgery
Rolapitant	70 to 200 mg	rec	PO	before surgery
Scopolamine	1.5 mg	NA	TD	before surgery
Tropisetron (IV)*	2 mg	rec	IV	at induction of AN

The table reported the most commonly used doses, routes, and time points of administration of drugs of direct interest for vomiting.

*Most of the studies investigated high doses, but recommended were also effective.

**Not used in any of the included studies with recommended dose.

Abbreviations: AN = anaesthesia; IM = intramuscular; IV = intravenous; NA = not applicable; PO = per oral; rec = recommended; TD = transdermal.