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. 2020 Oct 19;2020(10):CD012859. doi: 10.1002/14651858.CD012859.pub2

Comparison 7. Granisetron versus placebo.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
7.1 Vomiting within 0 to 24 hours 16 2270 Risk Ratio (IV, Random, 95% CI) 0.49 [0.39, 0.62]
7.1.1 Low dose 3 419 Risk Ratio (IV, Random, 95% CI) 0.82 [0.68, 0.99]
7.1.2 Recommended dose 14 1811 Risk Ratio (IV, Random, 95% CI) 0.44 [0.34, 0.56]
7.1.3 High dose 1 40 Risk Ratio (IV, Random, 95% CI) 0.24 [0.10, 0.58]
7.2 Serious adverse events 2 401 Risk Ratio (IV, Random, 95% CI) 1.57 [0.06, 38.32]
7.2.1 Recommended dose 2 401 Risk Ratio (IV, Random, 95% CI) 1.57 [0.06, 38.32]
7.3 Any adverse event 6 699 Risk Ratio (IV, Random, 95% CI) 0.92 [0.81, 1.06]
7.3.1 Low dose 1 121 Risk Ratio (IV, Random, 95% CI) 0.93 [0.80, 1.08]
7.3.2 Recommended dose 3 478 Risk Ratio (IV, Random, 95% CI) 0.92 [0.66, 1.29]
7.3.3 High dose 1 40 Risk Ratio (IV, Random, 95% CI) 0.80 [0.25, 2.55]
7.3.4 NA dose 1 60 Risk Ratio (IV, Random, 95% CI) 0.83 [0.28, 2.44]
7.4 Headache 15 1639 Risk Ratio (IV, Random, 95% CI) 1.28 [1.03, 1.61]
7.4.1 Low dose 1 121 Risk Ratio (IV, Random, 95% CI) 1.98 [0.63, 6.25]
7.4.2 Recommended dose 12 1418 Risk Ratio (IV, Random, 95% CI) 1.23 [0.95, 1.60]
7.4.3 High dose 1 40 Risk Ratio (IV, Random, 95% CI) 0.50 [0.05, 5.08]
7.4.4 NA dose 1 60 Risk Ratio (IV, Random, 95% CI) 0.50 [0.05, 5.22]
7.5 Sedation/drowsiness 9 850 Risk Ratio (IV, Random, 95% CI) 1.08 [0.89, 1.30]
7.5.1 Recommended dose 7 750 Risk Ratio (IV, Random, 95% CI) 1.08 [0.89, 1.30]
7.5.2 High dose 1 40 Risk Ratio (IV, Random, 95% CI) 3.00 [0.13, 69.52]
7.5.3 NA dose 1 60 Risk Ratio (IV, Random, 95% CI) 1.00 [0.07, 15.26]
7.6 Extrapyramidal symptoms 5 330 Risk Ratio (IV, Random, 95% CI) Not estimable
7.6.1 Recommended dose 5 330 Risk Ratio (IV, Random, 95% CI) Not estimable
7.7 Constipation 3 230 Risk Ratio (IV, Random, 95% CI) 0.61 [0.20, 1.90]
7.7.1 Recommended dose 3 230 Risk Ratio (IV, Random, 95% CI) 0.61 [0.20, 1.90]
7.8 Arrhythmia 1 50 Risk Ratio (IV, Random, 95% CI) Not estimable
7.8.1 Recommended dose 1 50 Risk Ratio (IV, Random, 95% CI) Not estimable