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. 2020 Oct 19;2020(10):CD012859. doi: 10.1002/14651858.CD012859.pub2

Jamwal 2016.

Study characteristics
Methods Study design: randomized controlled trial
Study grouping: 3 groups, monoprophylaxis
Participants Baseline characteristics
Ondanstron (group O)

  • Assessed for eligibility (n): ‐

  • Enrolled (n): ‐

  • Randomized (n): 50

  • Received treatment (n): NA

  • Analysed (n): 50

  • Age (mean ± SD, median (IQR), median (range)): 38.32 ± 10.59

  • Weight (mean ± SD, median (IQR), median (range)): 58.94 ± 5.09

  • BMI (mean ± SD, median (IQR), median (range)): NA

  • ASA I/II/III/IV (n): NA/NA/0/0

  • Gender (female in %): 100

  • Non‐smoker (%): NA

  • History of PONV/motion sickness (%): NA

  • Type of general anaesthesia: inhalational anaesthesia (N₂O)

  • Duration of anaesthesia or surgery (in min; as mean or median): 65.20

  • Use of perioperative opioids (if yes, which?): NA

  • Type of surgery: laparoscopic cholecystectomy


Ramosetron (group R)

  • Assessed for eligibility (n): ‐

  • Enrolled (n): ‐

  • Randomized (n): 50

  • Received treatment (n): NA

  • Analysed (n): 50

  • Age (mean ± SD, median (IQR), median (range)): 38.46 ± 9.15

  • Weight (mean ± SD, median (IQR), median (range)): 59.04 ± 4.81

  • BMI (mean ± SD, median (IQR), median (range)): NA

  • ASA I/II/III/IV (n): NA/NA/0/0

  • Gender (female in %): 100

  • Non‐smoker (%): NA

  • History of PONV/motion sickness (%): NA

  • Type of general anaesthesia: inhalational anaesthesia (N₂O)

  • Duration of anaesthesia or surgery (in min; as mean or median): 71.22

  • Use of perioperative opioids (if yes, which?): NA

  • Type of surgery: laparoscopic cholecystectomy


Palonosetron (group P)

  • Assessed for eligibility (n): ‐

  • Enrolled (n): ‐

  • Randomized (n): 50

  • Received treatment (n): NA

  • Analysed (n): 50

  • Age (mean ± SD, median (IQR), median (range)): 38.94 ± 9.99

  • Weight (mean ± SD, median (IQR), median (range)): 58.08 ± 5.84

  • BMI (mean ± SD, median (IQR), median (range)): NA

  • ASA I/II/III/IV (n): NA/NA/0/0

  • Gender (female in %): 100

  • Non‐smoker (%): NA

  • History of PONV/motion sickness (%): NA

  • Type of general anaesthesia: inhalational anaesthesia (N₂O)

  • Duration of anaesthesia or surgery (in min; as mean or median): 69.50

  • Use of perioperative opioids (if yes, which?): NA

  • Type of surgery: laparoscopic cholecystectomy


Included criteria: female, 25 to 55 years of age, ASA I and II, undergoing laparoscopic cholecystectomy
Excluded criteria: received antiemetic 24 hours before surgery, concomitant administration of steroids and psychotropic drugs, pregnant or lactating, known prolonged QTc interval or bundle branch block, chemotherapy and allergy to the drugs used in the study
Pretreatment: baseline characteristics (age, weight, ASA): no. Potential effect modifiers (gender, duration of anaesthesia): no; (history of PONV/motion sickness, non‐smoker, perioperative opioids): unclear
Interventions Intervention characteristics
Ondanstron (group O)

  • Dose: 4 mg

  • Time point of administration: 3 minutes before induction of anaesthesia

  • Route of administration: IV

  • Rescue antiemetics (if yes, which?): metoclopramide 10 mg IV


Ramosetron (group R)

  • Dose: 0.3 mg

  • Time point of administration: 3 minutes before induction of anaesthesia

  • Route of administration: IV

  • Rescue antiemetics (if yes, which?): metoclopramide 10 mg IV


Palonosetron (group P)

  • Dose: 0.075 mg

  • Time point of administration: 3 minutes before induction of anaesthesia

  • Route of administration: IV

  • Rescue antiemetics (if yes, which?): metoclopramide 10 mg IV
Outcomes Vomiting (0 to 2 hours)

  • Outcome type: dichotomous outcome


Vomiting (12 to 24 hours)

  • Outcome type: dichotomous outcome


QT prolongation (0 to 2 hours, 2 to 6 hours, 6 to 12 hours, 12 to 24 hours, 24 to 48 hours)

  • Outcome type: dichotomous outcome


Headache (0 to 48 hours)

  • Outcome type: dichotomous outcome


Sedation/drowsiness (0 to 48 hours)

  • Outcome type: dichotomous outcome
Identification Sponsorship source: NA
Country: India
Setting: single‐centre
Author's name: Anju Jamwal
Institution: Department of Anaesthesia, Govt Medical College Jammu J India 180001
Email: NA
Address: Department of Anaesthesia, Govt. Medical College Jammu J India 180001
Language: English
Duration of study: NA
Trial registry number: NA
Study's primary outcome: NA
Notes None
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Quote: "...were randomly divided into 3 groups with 50 patients each"
Judgement comment: no statement on the randomization method
Allocation concealment (selection bias) Unclear risk Judgement comment: no statement
Blinding of participants and personnel (performance bias)
All outcomes Unclear risk Judgement comment: no statement
Blinding of outcome assessment (detection bias)
All outcomes Unclear risk Judgement comment: no statement
Incomplete outcome data (attrition bias)
All outcomes Low risk Judgement comment: no missing outcome data
Selective reporting (reporting bias) Unclear risk Judgement comment: no reference to study protocol or trial registry number reported
Other bias Unclear risk Quote: "there was no statistically significant difference in all three groups with respect to age, weight and duration of surgery"
Judgement comment: baseline characteristics (age, weight, ASA): no. Potential effect modifiers (gender, duration of anaesthesia): no; (history of PONV/motion sickness, non‐smoker, perioperative opioids): unclear