Jung 2013.

Study characteristics
Methods	Study design: randomized controlled trial Study grouping: 3 groups, monoprophylaxis, dose‐finding study
Participants	Baseline characteristics Aprepitant (A80 group) Assessed for eligibility (n): ‐ Enrolled (n): ‐ Randomized (n): 40 Received treatment (n): 40 Analysed (n): 40 Age (mean ± SD, median (IQR), median (range)): 46 ± 5 Weight (mean ± SD, median (IQR), median (range)): 58 ± 9 BMI (mean ± SD, median (IQR), median (range)): NA ASA I/II/III/IV (n): NA/NA/0/0 Gender (female in %): 100 Non‐smoker (%): 38 History of PONV/motion sickness (%): 1/3 Type of general anaesthesia: inhalational anaesthesia (isoflurane) Duration of anaesthesia or surgery (in min; as mean or median): 123 Use of perioperative opioids (if yes, which?): 5 patients received ketorolac 30 mg IV; 2 patients received fentanyl 50 µg IV Type of surgery: laparoscopic total hysterectomy Aprepitant (A125 group) Assessed for eligibility (n): ‐ Enrolled (n): ‐ Randomized (n): 40 Received treatment (n): 40 Analysed (n): 40 Age (mean ± SD, median (IQR), median (range)): 46 ± 5 Weight (mean ± SD, median (IQR), median (range)): 59 ± 7 BMI (mean ± SD, median (IQR), median (range)): NA ASA I/II/III/IV (n): NA/NA/0/0 Gender (female in %): 100 Non‐smoker (%): 38 History of PONV/motion sickness (%): 1/4 Type of general anaesthesia: inhalational anaesthesia (isoflurane) Duration of anaesthesia or surgery (in min; as mean or median): 122 Use of perioperative opioids (if yes, which?): 4 patients received ketorolac 30 mg IV; 3 patients received fentanyl 50 µg IV Type of surgery: laparoscopic total hysterectomy Placebo Assessed for eligibility (n): ‐ Enrolled (n): ‐ Randomized (n): 40 Received treatment (n): 40 Analysed (n): 40 Age (mean ± SD, median (IQR), median (range)): 46 ± 6 Weight (mean ± SD, median (IQR), median (range)): 59 ± 8 BMI (mean ± SD, median (IQR), median (range)): NA ASA I/II/III/IV (n): NA/NA/0/0 Gender (female in %): 100 Non‐smoker (%): 37 History of PONV/motion sickness (%): 0/2 Type of general anaesthesia: inhalational anaesthesia (isoflurane) Duration of anaesthesia or surgery (in min; as mean or median): 126 Use of perioperative opioids (if yes, which?): 4 patients received ketorolac 30 mg IV; 2 patients received fentanyl 50 µg IV Type of surgery: laparoscopic total hysterectomy Included criteria: ASA I or II, 21 to 60 years of age, scheduled for elective laparoscopic total hysterectomy Excluded criteria: liver, neurological, and active pulmonary disease; cardiac arrhythmia; allergy to any perioperative medication used in this study Pretreatment: baseline characteristics (age, weight, ASA): no. Potential effect modifiers (gender, duration of anaesthesia, non‐smoker, history of PONV/motion sickness, perioperative opioids): no
Interventions	Intervention characteristics Aprepitant (A80 group) Dose: 80 mg Time point of administration: 2 hours before induction Route of administration: PO Rescue antiemetics (if yes, which?): 8% (dexamethasone 5 mg, metoclopramide 10 mg) Aprepitant (A125 group) Dose: 125 mg Time point of administration: 2 hours before induction Route of administration: PO Rescue antiemetics (if yes, which?): 10% (dexamethasone 5 mg, metoclopramide 10 mg) Placebo Dose: 10 mL saline Time point of administration: 2 hours before induction Route of administration: PO Rescue antiemetics (if yes, which?): 20% (dexamethasone 5 mg, metoclopramide 10 mg)
Outcomes	Vomiting (0 to 2 hours) Outcome type: dichotomous outcome Vomiting (2 to 24 hours) Outcome type: dichotomous outcome Headache (0 to 48 hours) Outcome type: dichotomous outcome Adverse events (general notes in the publication, 24 hours' observation) Outcome type: general notes on side effects
Identification	Sponsorship source: NA Country: South Korea Setting: inpatient, single‐centre Author's name: Hong Seuk Yang Institution: Department of Anesthesiology and Pain Medicine, Asan Medical Center, College of Medicine University of Ulsan, South Korea Email: hsyang@amc.seoul.kr Address: Department of Anesthesiology and Pain Medicine, Asan Medical Center, College of Medicine University of Ulsan, 388‐1 Pungnap‐dong Songpa‐gu, Seoul 138‐736, South Korea Duration of study: NA Language: English Study's primary outcome: incidence of PONV Trial registry number: NCT01440673
Notes	None
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Quote: "a randomization list was generated using Microsoft Excel’s random function"
Allocation concealment (selection bias)	Unclear risk	Judgement comment: no statement
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Quote: "to achieve blinding, an independent researcher prepared the study solutions, which consisted of a drinking cup wrapped in foil containing 10 ml saline in the control group and a cup containing dissolved aprepitant tablets in the treatment groups"
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Quote: "recorded throughout the hospital stay by specially trained personnel blinded to all patient treatments"
Incomplete outcome data (attrition bias) All outcomes	Low risk	Judgement comment: no missing outcome data
Selective reporting (reporting bias)	Unclear risk	Judgement comment: NCT01440673 (retrospective registration)
Other bias	Low risk	Quote: "the three groups of patients did not differ in characteristics, surgery or anesthesia duration, or and Apfel’s simplified risk score (Table 1)" Judgement comment: baseline characteristics (age, weight, ASA): no. Potential effect modifiers (gender, duration of anaesthesia, non‐smoker, history of PONV/motion sickness, perioperative opioids): no