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. 2020 Oct 19;2020(10):CD012859. doi: 10.1002/14651858.CD012859.pub2

Quan 2007.

Study characteristics
Methods Study design: randomized controlled trial
Study grouping: 3 groups, monoprophylaxis
Participants Baseline characteristics
Ondansetron

  • Assessed for eligibility (n): ‐

  • Enrolled (n): ‐

  • Randomized (n): 120

  • Received treatment (n): NA

  • Analysed (n): 120

  • Age (mean ± SD, median (IQR), median (range)): 47.5 ± 14.1

  • Weight (mean ± SD, median (IQR), median (range)): 63.6 ± 10.6

  • BMI (mean ± SD, median (IQR), median (range)): NA

  • ASA I/II/III/IV (n): NA/NA/0/0

  • Gender (female in %): 76.7

  • Non‐smoker (%): 92.5

  • History of PONV/motion sickness (%): 4.2

  • Type of general anaesthesia: inhalational anaesthesia (isoflurane, enflurane)

  • Duration of anaesthesia or surgery (in min; as mean or median): 106.4

  • Use of perioperative opioids (if yes, which?): 15% of patients received postoperative opioids

  • Type of surgery: elective operation


Tropisetron

  • Assessed for eligibility (n): ‐

  • Enrolled (n): ‐

  • Randomized (n): 120

  • Received treatment (n): NA

  • Analysed (n): 118

  • Age (mean ± SD, median (IQR), median (range)): 44.3 ± 13.8

  • Weight (mean ± SD, median (IQR), median (range)): 62.7 ± 10.6

  • BMI (mean ± SD, median (IQR), median (range)): NA

  • ASA I/II/III/IV (n): NA/NA/0/0

  • Gender (female in %): 78.0

  • Non‐smoker (%): 95.8

  • History of PONV/motion sickness (%): 2.5

  • Type of general anaesthesia: inhalational anaesthesia (isoflurane, enflurane)

  • Duration of anaesthesia or surgery (in min; as mean or median): 98.6

  • Use of perioperative opioids (if yes, which?): 12.7% of patients received postoperative opioids

  • Type of surgery: elective operation


Granisetron

  • Assessed for eligibility (n): ‐

  • Enrolled (n): ‐

  • Randomized (n): 120

  • Received treatment (n): NA

  • Analysed (n): 118

  • Age (mean ± SD, median (IQR), median (range)): 44.9 ± 14.9

  • Weight (mean ± SD, median (IQR), median (range)): 62.7 ± 12.0

  • BMI (mean ± SD, median (IQR), median (range)): NA

  • ASA I/II/III/IV (n): NA/NA/0/0

  • Gender (female in %): 76.3

  • Non‐smoker (%): 97.5

  • History of PONV/motion sickness (%): 4.2

  • Type of general anaesthesia: inhalational anaesthesia (isoflurane, enflurane)

  • Duration of anaesthesia or surgery (in min; as mean or median): 112.7

  • Use of perioperative opioids (if yes, which?): 15.3% of patients received postoperative opioids

  • Type of surgery: elective operation


Included criteria: ASA I or II, 18 to 75 years of age, received elective operation with endotracheal intubation and general anaesthesia
Excluded criteria: obesity; pregnancy; breastfeeding; preoperative use of antiemetics or drugs; severe cardiac, liver, renal, pulmonary, neurological, or psychiatric disease, postoperative care (?), use of gastric tube
Pretreatment: baseline characteristics (age, weight, ASA): no. Potential effect modifiers (gender, duration of anaesthesia, non‐smoker, history of PONV/motion sickness, perioperative opioids): no
Interventions Intervention characteristics
Ondansetron

  • Dose: 4 mg

  • Time point of administration: before anaesthesia induction

  • Route of administration: IV

  • Rescue antiemetics (if yes, which?): metoclopramide


Tropisetron

  • Dose: 5 mg

  • Time point of administration: before anaesthesia induction

  • Route of administration: IV

  • Rescue antiemetics (if yes, which?): metoclopramide


Granisetron

  • Dose: 3 mg

  • Time point of administration: before anaesthesia induction

  • Route of administration: IV

  • Rescue antiemetics (if yes, which?): metoclopramide
Outcomes Vomiting (0 to 24 hours)

  • Outcome type: dichotomous outcome


Nausea (0 to 24 hours)

  • Outcome type: dichotomous outcome


Complete response (no PONV) in 24 hours

  • Outcome type: dichotomous outcome


Adverse events (general notes in the publication, 24 hours' observation)

  • Outcome type: general notes on side effects
Identification Sponsorship source: NA
Country: China
Setting: inpatient, single‐centre
Author's name: Xiang Quan
Institution: Department of Anesthesiology, PUMC Hospital, CAMS and PUMC, Beijing, China
Email: quan79102@sina.com
Address: Department of Anesthesiology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China
Duration of study: NA
Language: Chinese (Google Translator)
Study's primary outcome: NA
Trial registry number: NA
Notes None
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Judgement comment: quote: "randomized". No further information on sequence generation provided
Allocation concealment (selection bias) Unclear risk Judgement comment: no statement
Blinding of participants and personnel (performance bias)
All outcomes Unclear risk Judgement comment: insufficient information on blinding ("double‐blind")
Blinding of outcome assessment (detection bias)
All outcomes Unclear risk Judgement comment: insufficient information on blinding ("double‐blind")
Incomplete outcome data (attrition bias)
All outcomes Low risk Judgement comment: quote: "two patients with strong back pain after surgery were excluded and two patients were lost during the study" (translated)
Selective reporting (reporting bias) Unclear risk Judgement comment: no reference to a study protocol or trial registry number reported
Other bias Low risk Judgement comment: baseline characteristics (age, weight, ASA): no. Potential effect modifiers (gender, duration of anaesthesia, non‐smoker, history of PONV/motion sickness, perioperative opioids): no