Schuh 1987.

Study characteristics
Methods	Study design: randomized controlled trial Study grouping: 2 groups, monoprophylaxis
Participants	Baseline characteristics Droperidol (DHB) Assessed for eligibility (n): ‐ Enrolled (n): ‐ Randomized (n): 20 Received treatment (n): NA Analysed (n): 20 Age (mean ± SD, median (IQR), median (range)): 48 ± 13.9 Weight (mean ± SD, median (IQR), median (range)): 71 ± 13.1 BMI (mean ± SD, median (IQR), median (range)): NA ASA I/II/III/IV (n): NA/NA/0/0 Gender (female in %): 85 Non‐smoker (%): NA History of PONV/motion sickness (%): NA Type of general anaesthesia: balanced anaesthesia (enflurane, N₂O, fentanyl) Duration of anaesthesia or surgery (in min; as mean or median): 80 Use of perioperative opioids (if yes, which?): 0.33 mg intraoperative fentanyl, tramadol postoperative Type of surgery: cholecystectomy TTS‐Scopalamine Assessed for eligibility (n): ‐ Enrolled (n): ‐ Randomized (n): 20 Received treatment (n): NA Analysed (n): 20 Age (mean ± SD, median (IQR), median (range)): 50 ± 12.3 Weight (mean ± SD, median (IQR), median (range)): 70 ± 12.1 BMI (mean ± SD, median (IQR), median (range)): NA ASA I/II/III/IV (n): NA/NA/0/0 Gender (female in %): 70 Non‐smoker (%): NA History of PONV/motion sickness (%): NA Type of general anaesthesia: balanced anaesthesia (enflurane, N₂O, fentanyl) Duration of anaesthesia or surgery (in min; as mean or median): 71 Use of perioperative opioids (if yes, which?): 0.35 mg intraoperative fentanyl, tramadol postoperative Type of surgery: cholecystectomy Included criteria: ASA I or II, cholecystolithiasis undergoing cholecystectomy under standardized balanced anaesthesia Excluded criteria: over 70 years of age, glaucoma, micturition disturbance, intake of anticholinergics, history of psychiatric therapy Pretreatment: baseline characteristics (age, weight, ASA): no. Potential effect modifiers (gender, duration of anaesthesia): no; (history of PONV/motion sickness, non‐smoker, perioperative opioids): unclear
Interventions	Intervention characteristics Droperidol (DHB) Dose: 7.5 mg, placebo patch Time point of administration: at induction of anaesthesia Route of administration: IV Rescue antiemetics (if yes, which?): 15% (metoclopramide) TTS‐Scopalamine Dose: NA Time point of administration: on the evening before surgery Route of administration: transdermal Rescue antiemetics (if yes, which?): 60% (metoclopramide)
Outcomes	Vomiting (2 to 6 hours) Outcome type: dichotomous outcome Adverse events (general notes in the publication, observation until the afternoon on the first postoperative day) Outcome type: general notes on side effects
Identification	Sponsorship source: NA Country: Germany Setting: inpatient, single‐centre Author's name: Rainer Schuh Institution: Anästhesieabteilung, Elisabethenstift, Darmstadt Email: NA Address: Anästhesieabteilung, Elisabethenstift, Landgraf‐Georg‐Straße 100, 6100 Darmstadt Duration of study: 1985 to 1986 Language: German (2 German reviewers) Study's primary outcome: NA Trial registry number: NA
Notes	None
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Quote: "Ppatienten wurden prospektiv mit einer Zufallszahlentabelle zwei Gruppen randomisiert zugeordnet. Mit..." Judgement comment: random number table
Allocation concealment (selection bias)	Unclear risk	Judgement comment: no statement
Blinding of participants and personnel (performance bias) All outcomes	High risk	Quote: "tabelle zwei Gruppen randomisiert zugeordnet. Mit der Anwendung eines Placebopflasters in der DHB‐Gruppe wurde die Untersuchung einfach blind durchgeführt. Die angewendeten statistischen Methoden richteten" Judgement comment: personnel was not blinded
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Judgement comment: no statement
Incomplete outcome data (attrition bias) All outcomes	Low risk	Judgement comment: no missing outcome data
Selective reporting (reporting bias)	Unclear risk	Judgement comment: no reference to a study protocol or trial registry number reported
Other bias	Unclear risk	Quote: "hinsichtlich der anthropometrischen Daten (Tab. 1) ergaben sich ‐ auch bei der Geschlechtsverteilung ‐ keine signifikanten Unterschiede" Judgement comment: baseline characteristics (age, weight, ASA): no. Potential effect modifiers (gender, duration of anaesthesia): no; (history of PONV/motion sickness, non‐smoker, perioperative opioids): unclear