Schultz 2003.

Study characteristics
Methods	Study design: randomized controlled trial Study grouping: 2 groups, monoprophylaxis
Participants	Baseline characteristics Droperidol Assessed for eligibility (n): ‐ Enrolled (n): ‐ Randomized (n): NA Received treatment (n): NA Analysed (n): 24 Age (mean ± SD, median (IQR), median (range)): 50.2 ± 13.7 Weight (mean ± SD, median (IQR), median (range)): NA BMI (mean ± SD, median (IQR), median (range)): NA ASA I/II/III/IV (n): NA Gender (female in %): 100 Non‐smoker (%): NA History of PONV/motion sickness (%): NA Type of general anaesthesia: inhalational anaesthesia (Isoflurane, N₂O) Duration of anaesthesia or surgery (in min; as mean or median): 197 Use of perioperative opioids (if yes, which?): NA Type of surgery: vaginal or total abdominal hysterectomy, laparoscopy, tubal ligation, tubal re‐anastomosis, bladder suspension, Burch procedure, anterior‐posterior repair or myomectomy Placebo Assessed for eligibility (n): ‐ Enrolled (n): ‐ Randomized (n): NA Received treatment (n): NA Analysed (n): 25 Age (mean ± SD, median (IQR), median (range)): 47.7 ± 12.3 Weight (mean ± SD, median (IQR), median (range)): NA BMI (mean ± SD, median (IQR), median (range)): NA ASA I/II/III/IV (n): NA Gender (female in %): 100 Non‐smoker (%): NA History of PONV/motion sickness (%): NA Type of general anaesthesia: inhalational anaesthesia (Isoflurane, N₂O) Duration of anaesthesia or surgery (in min; as mean or median): 153 Use of perioperative opioids (if yes, which?): NA Type of surgery: vaginal or total abdominal hysterectomy, laparoscopy, tubal ligation, tubal re‐anastomosis, bladder suspension, Burch procedure, anterior‐posterior repair or myomectomy Included criteria: over 18 years of age, able to read and write English, low risk of anaesthesia issues, scheduled for inpatient surgery after gynaecological surgery Excluded criteria: pregnancy, surgery for cancer within previous 5 years, chemotherapy or radiation therapy within 5 years, antiemetic within 24 hours before surgery, previous use of acupressure bands, peripheral neuropathy Pretreatment: baseline characteristics (age): no; (weight, BMI, ASA): unclear. Potential effect modifiers (gender): no; (history of PONV/motion sickness, non‐smoker, perioperative opioids): unclear; (duration of anaesthesia): yes
Interventions	Intervention characteristics Droperidol Dose: 1.25 mg Time point of administration: before or with induction, "an anesthesiologist gave the study drug and documented the time of administration" Route of administration: IV Rescue antiemetics (if yes, which?): NA Placebo Dose: NA Time point of administration: before or with induction, "an anesthesiologist gave the study drug and documented the time of administration" Route of administration: IV Rescue antiemetics (if yes, which?): NA
Outcomes	Nausea (0 to 24 hours) Outcome type: dichotomous outcome Adverse events (general notes in the publication, 24 hours' observation) Outcome type: general notes on side effects
Identification	Sponsorship source: Seabands UK Ltd contributed the Seabands for the study Country: USA Setting: inpatient, single‐centre Author's name: Alyce A. Schultz Institution: New England Rehabilitation Hospital of Portland Email: Schula@mmc.org Address: Alyce A. Schultz, RN, PhD, Nurse Researcher, Maine Medical Center, 22 Bramhall Street, Portland, ME 04102, USA Duration of study: July 1999 to August 2000 Language: English Study's primary outcome: nausea Trial registry number: NA
Notes	Two out of 4 groups relevant (acupressure bands)
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Judgement comment: quote: "random table number"
Allocation concealment (selection bias)	Unclear risk	Judgement comment: quote: "study envelopes ... were prepared by the principal investigator and the study pharmacist..." Not stated; "sequentially numbered, opaque, and sealed envelopes" (SNOSE). Unclear who performed randomization
Blinding of participants and personnel (performance bias) All outcomes	High risk	Judgement comment: quote: "the envelope containing the study group designation was opened by the admitting nurse and placed on the front of the subject's chart" "An anesthesiologist gave the study drug". Study personnel probably was not blinded
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Judgement comment: no statement on blinding of outcome assessors
Incomplete outcome data (attrition bias) All outcomes	High risk	Judgement comment: quote: "one hundred and forty‐three women consented the study. One hundred and three women completed the hospital phase of the study...the most frequent reason for attrition was non‐administration of the study drug". High rate of missing outcome data (> 15%)
Selective reporting (reporting bias)	Unclear risk	Judgement comment: no reference to a study protocol or trial registry number reported
Other bias	High risk	Judgement comment: baseline characteristics (age): no; (weight, BMI, ASA): unclear. Potential effect modifiers (gender): no; (history of PONV/motion sickness, non‐smoker, perioperative opioids): unclear; (duration of anaesthesia): yes