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. 2021 May 4;14:63. doi: 10.1186/s13048-021-00804-1

Table 5.

Multivariate Cox proportional hazards analysis for PFS and OS used to adjust risk associated prognostic clinical features

Pure group (n = 164) PFS OS
HR (95%CI) p-value HR (95%CI) p-value
Parity 0.906 (0.508–1.615) 0.738 / /
CA-125(before) 1.000 (0.999–1.000) 0.595 1.646 (0.403–6.725) 0.487
CA-125(after) 1.002 (1.000–1.005) 0.044 / /
FIGO 1.722 (0.990–2.994) 0.054 3.981 (1.821–8.706) 0.001
EM-related 4.014 (1.056–15.262) 0.041 0.925 (0.272–3.146) 0.047
Residual disease 0.915 (0.475–1.766) 0.792 1.389 (0.823–2.346) 0.219
Lymph Nodes excision 0.325 (0.078–1.346) 0.325 0.925 (0.272–3.146) 0.900
Mixed group (n = 47) PFS OS
HR (95%CI) p-value HR (95%CI) p-value
CA-125(before) 1.000 (0.999–1.001) 0.835 1.000 (1.000–1.001) 0.185
CA-125(after) 1.003 (0.998–1.008) 0.235 / /
FIGO 1.934 (0.211–17.700) 0.023 1.880 (0.699–5.059) 0.211
EM-related / / / /
Residual disease 1.490 (0.544–4.087) 0.544 1.030 (0.508–2.086) 0.935
Mixed with EC 0.070 (0.014–0.347) 0.001 0.425 (0.107–1.684) 0.223
Appendix excision 4.460 (0.350–56.794) 0.249 0.228 (0.041–1.258) 0.090
Lymph Nodes excision 1.934 (0.211–17.700) 0.559 1.030 (0.508–2.086) 0.935
2–4 stage of patients with pure cancer PFS
HR (95%CI) p-value
FIGO 2.918 (1.022–8.326) 0.045
R0 0.287 (0.110–0.749) 0.011

CA Cancer antigen; CA-125(before) CA-125 level before surgery; CI Confidence interval; FIGO International Federation of Gynecology and Obstetrics; HR Hazard ratio; OS Overall survival; PFS Progression-free survival. R0, Achieving optimal cytoreduction and/or removal of all macroscopic disease