5. Complier average causal effect analyses for eczema.

Complier	N trials	N intervention	N control	CACE		Intention‐to‐treat
				Pooled RR	95% CI	Pooled RR	95% CI
Primary CACE: ≥ 3 days of use over interventionperiod	3a	705	735	0.65	0.29 to 1.45	0.93	0.77 to 1.12
Sensitivity CACE: ≥ 5 days of use over intervention period	2b	667	699	0.74	0.26 to 2.09	0.95	0.79 to 1.15
7 days use over intervention period	3c	689	699	0.78	0.23 to 2.71	0.95	0.79 to 1.15
≥ 3 days of use over first 3 months of intervention period	2b	667	669	1.02	0.79 to 1.31	0.95	0.79 to 1.15
≥ 5 days of use over first 3 months of intervention period	2b	667	669	0.84	0.46 to 1.52	0.95	0.79 to 1.15
7 days use over first 3 months of intervention period	3c	689	726	0.83	0.34 to 2.03	0.95	0.79 to 1.15

^aChalmers 2020; Lowe 2018a; Skjerven 2020; Yonezawa 2018. ^bChalmers 2020; Skjerven 2020; Yonezawa 2018. ^cChalmers 2020; NCT03376243; Yonezawa 2018.