Migacheva 2018.

Study characteristics
Methods	Study design: randomised, controlled trial Treatment arms: 2 AD follow‐up: 12 months
Participants	Randomised: N = 63 Inclusion criteria: Family history of allergy Exclusion criteria:  Prematurity Supplementation (including short‐term use of children milk formulas in the maternity hospital) Appointment of probiotics Use of drugs by nursing mother Use of special means of baby skin care (emollients)
Interventions	Intervention: infants in the intervention group received full‐body emollient therapy (cream) twice a day starting within 3 weeks of birth in combination with supplementation of synbiotic containing LGG and fructo‐oligosaccharides at the age of 3 to 6 months Comparator: parents in the control group were asked to use no emollients and no pro/prebiotics during the study period Adherence to the application came in at 95.2% by the end of the study, which reassured that the process was feasible
Outcomes	Cumulative incidence of AD at 12 months, as assessed by a trained investigator Adverse events: no intervention‐related adverse events occurred
Identification	Country: Russia Sponsorship source: not reported
Declarations of interest	Not reported
Notes