Eichner 2020.

Study name	A Community‐based Assessment of Skin Care, Allergies, and Eczema (CASCADE)
Methods	Pragmatic, multi‐site, randomised, community‐based trial
Participants	Estimated enrolment: 1250
Interventions	Experimental: daily emollient Parents assigned to the intervention arm will receive a lipid‐rich emollient and educational materials promoting once‐daily full‐body emollient use until the infant is 24 months old. Parents will select 1 of 5 emollients to be mailed to the dyad's home at enrolment and approximately every 6 months for the duration of the study. These emollients include (1) CeraVe Healing Ointment, (2) Vaseline, (3) Cetaphil Cream, (4) CeraVe Cream, and (5) Vanicream Intervention: other: participant choice of over‐the‐counter emollients: Vaseline, Vanicream, CeraVe Healing Ointment, CeraVe Cream, Cetaphil Cream Comparator: no Intervention, natural skin Parents assigned to the control arm will receive educational materials promoting general infant skin care guidelines only and will be asked to refrain from emollient use unless dry skin develops (current standard of care guidelines)
Outcomes	Primary outcome Cumulative incidence of AD [Time Frame: 24 months] Secondary outcomes Parental report [Time Frame: 3, 6, 9, 12, 15, 18, and 24 months] Children's Eczema Questionnaire [Time Frame: 12 and 24 months] Sleep loss [Time Frame: 12 and 24 months] Prescription topical skin medication [Time Frame: 3, 6, 9, 12, 15, 18, 21, and 24 months] Asthma risk [Time Frame: 12 and 24 months] Food allergy symptoms [Time Frame: 12 and 24 months] Food allergy clinician diagnosed [Time Frame: 12 and 24 months] Global Health Status [Time Frame: 12 and 24 months] Atopic dermatitis severity 1 [Time Frame: 12 and 24 months] Atopic dermatitis severity 2 [Time Frame: 12 and 24 months] Atopic dermatitis severity 3 [Time Frame: 12 and 24 months] Atopic dermatitis severity 4 [Time Frame: 12 and 24 months] Atopic dermatitis severity 5 [Time Frame: 12 and 24 months]
Starting date	3 July 2018
Contact information	LeAnn Michaels ‐ michaell@ohsu.edu Clara Stemwedel ‐ stemwedc@ohsu.edu
Notes